Name: Oscar Alfredo Brown

Place of birth: La Plata, Buenos Aires.

Date of birth: 07/15/62.

Marital status: single.

Nationality: Argentina.

Passport #: 14988917N

Home address: calle 120 # 1460, La Plata (1900), Buenos Aires, Argentina.
Phone: (54 2)214232680.

Actual position: Associate Researcher from National Research Council of Science and technology (CONICET), Argentina.

Email: 120oscar@iwinds.com.ar OR browneconomia@gmail.com

EDUCATION

1981 Chemical Technologist. Albert Thomas National School. La Plata, Buenos
Aires, Argentina.

1988 Bs Chemistry. Faculty of Exact Sciences, National University of La Plata
(UNLP). La Plata, Buenos Aires, Argentina.

1990 Ms Biochemistry. Faculty of Exact Sciences, UNLP. La Plata, Buenos
Aires, Argentina.
1992-1993 ¨ MBA, Ms in RRHH and Accountant Technician¨. Research Assistant. Department of Biological Sciences, University of Arkansas Fayetteville, Arkansas, USA.

1997 PhD. Faculty of Exact Sciences, UNLP. La Plata, Buenos Aires, Argentina.

MANAGING OF PERSONEL
8 Technicians, 4 Animal House Workers, 5 PhD students, 1 Post-doc and 1 Associate Research.

POST-GRADUATE COURSES

1989 “Endocrinology '89: Clinical & laboratory test for the diagnosis of
Endocrine pathology”. Faculty of Exact Sciences, UNLP. Argentina.

1991 “Parasites and health”. Children's Hospital of La Plata. Argentina.

1993 “Biological membranes: structure and molecular interactions”. Faculty of
Medicine, UNLP. Argentina.

1993 “Experimental nuclear spectrometry”. Faculty of Exact Sciences, UNLP.
Argentina.

1993 “Advanced enzymatic kinetics”. Faculty of Biochemistry & Pharmacy,
University of Buenos Aires (UBA). Argentina.

1995 “Training in molecular neurobiology and gene therapy” Laboratory of
Molecular and Cellular Neurobiology, Physiology Unit, School of
Molecular and Medical Biosciences, University of Wales, College of
Cardiff, UK.

2004 ¨Molecular Biology¨, Laboratory physiology with biophysics, “Faculty of
Medicine, UNLP. Argentina.

2005 ¨ Methodology of Radioisótopos¨. “. Faculty of Biochemistry & Pharmacy, UBA. Such course let to obtain the Licensee to work with radioactive material. The Licensee gives by the Nuclear Regulatory Authority (ARN).

TEACHING EXPERIENCE

1984 – 1989 Undergraduate Teaching Assistant. General Biology, Faculty of Exact
Sciences, UNLP. La Plata, Argentina.

1987 -1988 Teacher Substitute of Organic Chemistry I. Albert Thomas National
School. La Plata, Argentina.

1989 – 1990 Teaching Assistant. General Biology, Faculty of Exact Sciences, UNLP.

1990 – 1991 Instructor. General Biology, Faculty of Exact Sciences, UNLP.

1992-1995 Instructor. General Biology, Faculty of Exact Sciences, UNLP.

1996-2001 Associate Professor. General Biology, Faculty of Exact Sciences,
UNLP.

AWARDS

1993 Biannual price of “The Biochemical Federation” for the research work presented
At Latin-American proceedings of Clinical Biochemistry by the work: “Thymic hormones as mediators of the immunogonadotropha integration” O.A. Brown, Y.E. Sosa, R.G. Goya Latin-American proceedings of Clinical Biochemistry 28: 203-209 (1994). ARG

2007 Price of ¨The Medical Association of Argentine-Argentine Society of Pharmacology and Therapeutics¨ for the research work presented in Argentine Society of Pharmacology and Therapeutics by the work: ¨Restoration of reproductive function in immunodeficient mice by the way of the use gene therapy with the gene of the thymulin peptide¨P.C. Reggiani, E.V. Martínes, G.A. Camihort, G. Luna, O.A. Brown, R.G.Goya, G.M.Cónsole Argentine Society of Pharmacology and Therapeutics 1(41): 1-6 (2007).ARG

GRANTS

ONE´S OWN: 17

INSIDE THE RESPONSEBLE GROUP: 9

PAPERS

1. – “His tones and related nuclear preparations stimulate prolactin release in vitro” O.A. Brown, Y.E. Sosa, R.G. Goya. Medical Science Research, 21: 799-780 (1993). USA

2. – “Thymic hormones as mediators of the immunogonadotropha integration” O.A. Brown, Y.E. Sosa, R.G. Goya. Latin-American proceedings of Clinical Biochemistry 28: 203-209 (1994). ARG

3. – “In vitro studies on the thymus – pituitary axis in young and old rats” R.G. Goya, Y.E. Sosa, O.A. Brown, M. Dardenne. Annals of the New York Academy of Sciences 741: 108-114 (1994). USA

4. – “Hormonal modulation of antioxidant enzyme activities in young and old rats” A.D. Bolzan, O.A. Brown, R.G. Goya, M.S. Bianchi. Experimental Gerontology 30: 169-175 (1995). UK

5.- ” The thymic-neuroendocrine axis and it changes during aging” R.G. Goya, Y.E. Sosa, O.A. Brown, K. Godlike. International Journal of Thymology 3(5): 278-281 (1995). GERMANY

6.- “Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal ant peptide antibodies and their localization in pituitary cells and cortical neurons in vitro ” M.G. Castro, E. Morrison, M.J. Perone, O.A. Brown, C.A. Murray, I. Ahmed, A.V. Perkins, G. Europe-Finner, P.R. Lowenstein, E.A. Linton. Journal of Neuroendocrinology 8: 521-531 (1996). UK

7. – “Age-dependent prolactin-releasing activity of nucleoproteins” O.A. Brown, Y.E. Sosa, G.M. Cónsole, R.G. Goya. Mechanisms of Ageing and Development 89: 103-111 (1996). USA

8. – “Uptake of -(L)-iduronidase produced by retroviral transduced fibroblasts into neuronal and glial cells in vitro. Stewart K., Brown O.A., Morelli A.T., Fairbairn L.J., Lashford L.S., Cooper A., Hatton C.E., Dexter T.M., Castro M.G., Lowenstein P.R. Gene Therapy 4: 63-75 (1997). UK

9.- “Sexual dimorphism in the age changes of the pituitary lactotrophs in rats” Cónsole G.M., Gómez Dumm C.L., Brown O.A., Ferese C., Goya R.G. Mechanisms of Ageing and Development 95: 157-166 (1997). USA

10.-“Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type-1 (HSV-1) vector, but not recombinant adenovirus vectors”. Brown O.A., Santer R.M., Shering A.F., Larregina A.T., Morelli A.E., Southgate T.D., Castro M.G., Lowenstein P.R. Gene Therapy 4: 331-338 (1997). UK

11. – “Effect of the corticotrophin releasing hormone precursor on interleukin-6 release by human mononuclear cells” Salas M.A., Brown O.A., Perone M.J., Castro M.G., Goya R.G. Clinical Immunology and Immunopathology 85: 35-39 (1997). USA

12.-“Thyrotropin-releasing activity of histone H2A, H2B and peptide MB-35” Brown O.A., Sosa Y.E., Goya R.G. Peptides 18: 1315-1319 (1997). USA

13. – “His tones as extracellular messengers: effects on growth hormone secretion” Brown O.A., Sosa Y.E, Goya R.G. Cell Biology International 21: 787-792 (1997). USA

14. – “Gonadotrophin-releasing activity of histones H2A and H2B” Brown O.A., Sosa Y.E., Goya R.G. Cellular and Molecular Life Sciences 54: 288-294 (1998). SUIZA

15.- “Thymulin stimulates prolactin and thyrotropin release in an age-related manner” Brown O.A., Sosa Y.E., Bolognani F., Goya R.G. Mechanisms of Ageing and Development 104: 249-262 (1998). USA

16.- “Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells” M. Perone, C.A. Murray, O.A. Brown, S. Gibson., E.A. Linton, A.V. Perkins, P.R. Lowenstein, M.G. Castro. Molecular and Cellular Endocrinology 142:191-202 (1998). USA

17. “Hormonal Determinations” Gobello M.G., Brown O.A., Rondero J.R. Analecta Veterinaria 18: 71-81 (1999). ARG

18. – “The thymus-pituitary axis and its changes during aging” Goya R.G., Brown O.A., Bolognani F. NeuroImmunoModulation 6: 137-142 (1999). SUIZA

19.- “Growth hormone-releasing activity of thymulin on pituitary somatotropes is age dependent” Brown O.A., Sosa Y.E., Dardenne M., Pléau J.M., Goya R.G. Neuroendocrinology 69: 20-27 (1999). SUIZA

20. – ¨Studies on the gonadotrpin-releasing activity of thymulin: changes with age¨ Brown O.A., SOSA Y.E., Dardenne M., Pléau J.M., Goya R.G. Journal of Gerontology (Biological Sciences) 55: B170-176 (2000). USA

21.- “Studies on the prolactin-releasing mechanisms of Histones H2A and B”., Brown O.A., Sosa Y.E., Castro M.G., Goya R.G. Life Sciences 66: 2081-2089 (2000). USA

22.- “Glycolipid anchors are not sufficient to target proteins to the axonal plasma membrane in polarized cortical neurons” O.A. Brown, D. Bain, C. Preston, P. Clissold M.G. Castro, P.R. Lowenstein. Gene Therapy 7: 1947-1953 (2000). UK

23.- “Thymus and aging: potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models” Goya R.G., Cónsole G.M., Hereñú C.B., Brown O.A., Rimoldi O. J. Gerontology 48: 325-328 (2002). USA

24.- “Hypophysotropic activity of histone H3 in vivo” Brown O.A., Sosa Y.E., Naumovich D., Hereñú C.B.,Goya R.G. Peptides 24: 671-678 (2003). USA

25. – “Thymulin and the neuroendocrine system” Goya R.G., Brown O.A., Pléau J.M., Dardenne M. Peptides 25: 139-142 (2004). USA

26.- “Potential of gene therapy for the treatment of pituitary tumors” Goya R.G., Sarkar D.K., Brown O.A., Hereñú C.B. Current Gene Therapy 4: 79-87 (2004). USA

27.- “Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors” Carri N.G., Sosa Y.E., Brown O.A., Albariño C., Romanowski V., Goya R.G. Brain Research Bulletin 65: 17-22 (2005). USA

28. “The neuroendocrine system as a model to evaluate experimental gene therapy” Hereñú C., Brown O.A., Sosa Y.E., Morel G., Reggiani P., Bellini M., Goya R.G. Current Gene Therapy; 6(1): 125-129 (2006). USA
29.- ¨Gene therapy for long-term restoration of circulating thymulin in thymectomized mice and rats¨ Reggiani P., Hereñú C.B., Rimoldi O.J., Brown O.A., Pléau J.M., Dardenne M., Goya R.G. Gene Therapy 13(16): 1214-1221 (2006) . UK
30.-¨Peripheral and mesencephalic transfer of a syntethic gene for the thymic peptide thymulin¨. Morel G.R., Brown O.A., Reggiani P.C., Hereñú C.B., Portiansky E.L., Zuccolilli G.O., Pleau J.M., Dardenne M., Goya R.G. Brain Research Bulletin 69: 647-651 (2006).USA
31.- ¨Gene therapy in the neuroendócrine system¨. Hereñú C.B.,
Morel G.R., Reggiani P., Sosa Y.E., Brown O.A., Goya R.G Frontiers of Hormone Research 35:135-42 (2006). SUIZA
32.- ¨Restoration of reproductive function in immunodeficient mice by the way of the use gene therapy with the gene of the thymulin peptide¨P.C. Reggiani, E.V. Martínes, G.A. Camihort, G. Luna, O.A. Brown, R.G.Goya, G.M.Cónsole Argentine Society of Pharmacology and Terapeutics 1(41): 1-6 (2007).ARG

ABSTRACTS: 36

FELLOWSHIPS

1983 Undergraduate Fellowship from UNLP, La Plata, Argentine.

1985 Undergraduate Fellowship from Faculty of Exact Sciences, UNLP, La Plata,
Argentine.

1986 Undergraduate Fellowship from UNLP, La Plata, Argentine.

1991 Hospital Residency in the Interzonal Hospital of Acute Diseases of La Plata
from Buenos Aires Health Ministry, La Plata, Argentine.

1993 Training Fellowship from Scientific Research Committee of Buenos Aires (CIC),
La Plata, Argentine.

1994 Training Fellowship from National Research Council of Argentine (CONICET),
Buenos Aires, Argentine.

1995 Training Fellowship from British Council – Antorchas Foundation. From
January to July. Laboratory of Molecular and Cellular Neurobiology, Physiology
Unit, University of Wales, College of Cardiff, Cardiff, UK.

1996 Advanced Training Fellowship from National Research Council of Argentine
(CONICET), Buenos Aires, Argentine. Scored first in the merit order by the
Medical Sciences Committee of CONICET which is responsible of evaluate the
merits of each prospective candidate, from Argentine or abroad, postulated for a CONICET’s Fellowship in the Medical Science field.

HUMAN RESOURSES FORMATION

1997-1998 SUPERVISSOR of Veterinary Medical, Cristina gobello in the postgraduate course: Immunomethods in endocrinology with 140 h totals of theory and practice.

WORKS

1989 Substitute Clinical Technician. Hematology Laboratory, Private Institute
Of Clinical Medicine and Surgery. City Bell, Argentine.

1986 – 1989 Laboratory Technician. Interzonal Hospital of Acute Diseases (HIGA)
“José de San Martín”. La Plata, Argentina.

1992-1993 Research Assistant. Department of Biological Sciences, University of
Arkansas Fayetteville, Arkansas, USA. Grant # 0402-01450-21-0000 US/NSF/DCB-
92-96030/KAPLAN. Here I studied a MBA, Ms in RRHH and Technician in Accountant

1995-2002 General Manager of French Bank Branch La Plata. La Plata, Argentina.

OTHER ACTIVITIES NOT RELATED TO WORK ALONG MY LIFE

1) Eight to 13 years old on Saturday and Sunday instruction of target shooting, carabina, fusil and hand arms.
2) Nine to 20 years old 4 days a week Judo and 3 days a week Taekwondo.
3)Twenty years old teaching, Director of Docent Concourses Subcomision as part of Legal’s Affairs of Student Center, practice nintjitsu and was peasant of research in neuroscience.
4) Fitness and help to my friends for free to get the desire weight (w/o annabolics), etc.
From the seven photography and when learn to read did the reactive for develop black and white.

HOBIES

1) Photography
2) Read: E. de Bono, Tom Peters, V. Packard, S. Hawking, J. Cortazar, J.P. Sartre, S. Bouvuar, etc.
3) View a good movie
4) On vacations: adventure tourism: trekking around Lanin Nat. Park 50 Km/day on 7 days, mountains’ such al Lanin Volcan and Aconcagua.
5) On work: travel and stay some weeks for the sociologic experience
6) Scuba diving, matriculated

Others
The Resume shows that I am PhD in Biochemistry, that you don´t know is that when I renew in the second year my fellowship I resulted first (96/100) between 2500 people presented, and when I enter in the Research Career I resulted five between 2000 people presented both in the Commission of Medical Sciences at the National Research Council of Science and Technology (CONICET). At 2002 I ascended to Associated Researcher an independent position in which I have four Doctoral Fellows, one Post-Doc and one Research Assistant. But I not conform and desire emigrate, because CONICET give a so low salary that I can´t reached the end of the month and a low grant. When I was in U.K. and the money were not a conditioning factor (Fellowship of British Council of the 2000 pounds/month, and in the lab. I can buy at libitum, I publish five papers in six month, that was at ´95), I also was in USA with a visa HIB SS#: 430-81-6130 in ´92-´93 with First Nat. Bank P.O.Box 1287 Fayetteville, AR72702 account # 58127032 (if you want to know my state on taxes and bank)
YOU CAN THINK ABOUT IT OF DELETE BUT SOME ONO WILL BE INTERESTED AND GAIN. I WANT A BETTER SALARY TOGETHER WITH THE REGALIES FOR THIS I WRITE, BUT I´LL FOLLOW WITH OTHERS BUT TAKING THE IDEA THAT NO IDEA IS BUYER UNTILL SIGN THE AGREEMENT

Justin

Thats all I hear!

Why dont they think outside the box ?

The answer is NOT an alternative in the tank.

Its an alternative way of harnessing Power !

I know the answer to eliminate the COMPLETE need for fossil fuel.

I just dont have the funds or an investor yet.

Help ?