VentureBeat

updated

Physic Ventures, a San Francisco venture firm that invests in companies focused on healthcare and sustainable living for consumers, has finished raising its first fund of $159 million.

So far, Physic has put money into five companies, including sleep-inducing chocolate maker Dreamerz Food, the interactive exercise company Expresso Fitness and eco-friendly plastic producer Novomer.

Managing director Will Rosenzweig said that where traditional life science investors put money into things like drugs that are reimbursed by health-care providers, Physic will invest in products over which consumers have more decision power. A complete map of potential investment areas can be found here.

Physic started off in April 2007 with a $125 million commitment from consumer goods giant Uniliver, which was later reduced to take on investments from institutions, pension funds and strategic investors.

The firm seeks to exploit synergies between its strategic investors, like Unilever and healthcare giant Humana, and its various portfolio companies. Dreamerz Food products, for example, are carried in Pharmaca stores — another Physic investment.

Previous reports indicated that Physic had raised $190 million; Rosenzweig says the fund was oversubscribed to that amount, but the investment was cut back, and Unilever’s portion reduced to about half of the total.

Representing a potential medical quantum leap similar to, but even more important than the commercialization of X-ray imaging, Pacific BioSciences has taken a whopping $100 million to make it possible to affordably map out an individual’s entire genome in a matter of minutes, and for under $1,000 dollars.

While several startups, including 23andMe and deCODEme, are already offering cheap genetic testing for individuals, the technology Pacific Bio is looking at is about as different from those as looking at a satellite image of a town is to walking through it. The company is working on a system to “read” each DNA letter in a person’s genetic makeup, providing an in-depth view of every factor affecting a given person’s health.

The idea sounds fairly simple: Individial DNA molecules are captured in tiny holes on a chip, where they are pulled apart and rebuilt with enzymes identical to those present in the body, but with the addition of chemical markers. A type of digital camera takes a picture of the process, identifying the specific fragment being looked at. We covered the technology in more depth when it was first revealed, and have mentioned various competitors, most notably Complete Genomics and BioNanomatrix, who want to do sequencing for under $100.

In practice, of course, operating at such tiny scales is difficult, and accurately sequencing thousands of genes at once seems nearly impossible. But the company says it will be ready to commercialize by 2010, a Herculean feat if it can pull it off. The new funding indicates that it is at least gaining the confidence of venture capitalists.

If and when that happens, it will be time for early investors including Alloy Ventures, Kleiner Perkins Caufield & Byers, and Mohr Davidow Ventures — who collectively plowed more than $70 million into Pacific Bio over four previous rounds — to rake in the money.

However, it will just be the beginning for a whole new field of medical technology centered around finding uses for all the new information in individuals that becomes available. Preventative medicine is the obvious use, but others, like data mining for new cures and information on diseases, are also possible. Laws regulating the use (and misuse) of such information by insurers, employers and others will also have to be formulated.

A passel of new investors joined the funding, starting with co-leads Deerfield Management and Intel Capital. Also in were Morgan Stanley, Redmile Group, T. Rowe Price, and an unnamed “large financial institution.” Other previous investors Maverick Capital, AllianceBernstein, DAG Ventures and Teachers’ Private Capital also participated.

Stealthy Mountain View, Calif.-based ExploraMed NC4 has raised $18.5 million of an expected $20 million first funding round, I’m told. The medical-device startup doesn’t have a Web site, and doesn’t even seem to have its own address yet.

Instead, ExploraMed NC4 — the name is a placeholder intended to obscure the startup’s strategy — is still housed at ExploraMed, a medical-device incubator backed by New Enterprise Associates, among others. ExploraMed was founded in 1995 by Joshua Makower, an NEA venture partner and a Stanford consulting professor who also co-directs the university’s Biomedical Technology Innovation Program.

Makower confirmed the fundraising, but declined to say what NC4 will be doing. “I love to talk about my companies, but I’ve found there’s virtue in keeping things secret as long as possible from competitors who are just dying to know what we’re up to,” he said. “I’ve learned from experience that if they can get a whiff of what we’re doing, they’ll just copy it.” Makower is not the startup’s CEO, and says ExploraMed will announce NC4’s leader “at the right time.”

Investors in the NC4 round include NEA, Morgenthaler Partners and the Makower Family Trust. Makower said the company is still corralling individual investors who’ve expressed interest in contributing the remaining $1.5 million for the round.

ExploraMed has so far launched five device makers, several of which we’ve covered here at VentureBeat LifeScience. Its most recent companies include Vibrynt, a stealthy device maker that raised $16 million in Aug. 2007, and NeoTract, a Pleasanton, Calif., developer of devices for non-cancerous prostate growths, which raised a total of $21.4 million in its first round.

TODAY’S HEADLINES:

• Stent maker IDev Tech raises $25M (VentureWire)
• Xytis gets $15M for brain-injury drugs (VentureWire)
• Diagnostic maker Iris Biotech plans to go public, launch breast-cancer test (Edgar)
• RiverVest Venture Partners raises $75M life-science fund (release)
• Concentric Medical names Maria Sainz CEO (release)

[Note: I'm a little sad to announce that this will be my last life-science briefing at VentureBeat, although with luck, it won't be the end of my time here. Starting Monday, I'll be blogging regularly on the drug industry and healthcare over at BNET Industries, a new CNET venture, so drop by if you can. (Preparing for that move is the main reason non-briefing posts have been scarce recently.) I still hope to post here occasionally as well, since covering below-the-radar startups has been a blast, and I'm not ready to give it up quite yet.

It's been a great year -- my first VentureBeat post was on April 3, 2007 -- and I want to thank Matt for the opportunity to join you here, and all our regular readers and commenters for your time and your insights. As journalists, we're only as good as our sources and readers, and you guys have helped in countless ways to make me look much smarter than I really am. --D.P.H.]

Stent maker IDev Tech raises $25M – IDev Technologies, a Houston medical-device startup, raised $25 million in a third funding round, VentureWire reports. The company is developing a new type of stent for use in propping open the liver’s bile ducts .

The company’s existing investors, a group that includes Bay City Capital, Heron Capital, PTB Sciences and RiverVest Venture Partners, provided the funding. IDev had previously raised $24 million, according to VW.

Xytis gets $15M for brain-injury drugs – Irvine, Calif.-based Xytis, a biotech focused on disorders of the central nervous system, raised $15 million in an extension of its second funding round, VentureWire reports. Its backers included Atlas Venture, CDC Innovation, Sanderling Ventures and Ventech.

The company says it was founded in 2005 from the merger of Xytis Pharmaceuticals and Remergent. (Sounds more to me like Xytis swallowed Remergent, but they’re free to describe it however they’d like.) Its lead drug candidate, XY2405, blocks a cellular protein called the Bradykinin B2 receptor, a signaling molecule thought to promote inflammation.

Xytis is testing the drug as a potential treatment for traumatic brain injury; the molecule is currently in mid-stage, phase II trials. The company is also testing an antidepressant in early-stage trials.

Xytis raised half the money last August, then received the second $7.5 million in April, the company told VentureWire. It has previously raised $24.5 million in its current incarnation, and its “predecessor companies” pulled in $6.5 million.

Diagnostic maker Iris Biotech plans to go public, launch breast-cancer test – Santa Clara, Calif.-based Iris Biotechnologies, a developer of molecular diagnostic tests, is preparing to go public, VentureWire reports. The company plans a small offering on the OTC Bulletin Board — if I’m reading its latest SEC filing correctly, its existing shareholders will raise about $1.1 million, with no proceeds headed to the company  — and hopes to launch a breast-cancer test later this year.

Iris plans to use chips to measure gene activity in breast cancer, with the hope of predicting the odds that a surgically removed tumor will recur and, eventually, helping patients and doctors customize cancer treatment from an early stage. The company claims that it will be competitive with Genomic Health and Agendia, two companies with similar tests for predicting breast-cancer recurrence.

There’s something a little odd about Iris’ disclosures in the SEC forms, though. Iris doesn’t describe its technology, the genes it will test or how it settled on them in any detail, and spends almost as much time talking about its database of patient information and related computer technology as it does about its tests. While it may consider some or all of that information a trade secret — and disclosure requirements may well be looser for such a small offering — it’s still kind of unusual for a startup to ask outside investors to put up their money essentially on faith.

TODAY’S HEADLINES:

• HealthExtras buys venture-backed PBM HospiScript for $100M (release)
• Urological device-maker NeoTract adds $7.4M (VentureWire)
• RNAi-drug startup Intradigm seeks $35M (VentureWire)
• Israel’s Arbel Medical raises $3.5M for tumor cryotherapy (release)

HealthExtras buys venture-backed PBM HospiScript for $100M — HospiScript Services, a Montgomery, Ala., prescription-benefits manager, agreed to be acquired by HealthExtras of Rockville, Md. HealthExtras will pay $100 million in cash for the venture-backed firm, which services the hospice industry.

HospiScript had raised at least $4 million in funding, according to VentureWire. That amount represents a 2005 round that involved Advantage Capital Alabama and Waveland NCP Alabama Ventures. The company declined to say more about its funding history.

Both companies manage the use of prescription drugs — HealthExtras for corporate, government and nonprofit health plans, HospiScript for hospices — in ways that are intended to reduce costs. HealthExtras said the acquisition will help it expand in the fast-growing hospice space.

Urological device-maker NeoTract adds $7.4M – Pleasanton, Calif.,-based NeoTract (no Web site), a devicemaker focused on urological problems, added $7.4 million to its first round of financing, VentureWire reports. The new funding brings that round to a total of $21.4 million.

New Enterprise Associates provided the cash.

NeoTract is working on a device to treat benign prostate hyperplasia, which is a non-cancerous growth of the prostate. The company doesn’t describe its device, although it says the product should enter clinical trials next year.

TODAY’S HEADLINES:

• Stemline Therapeutics, cancer stem-cell startup, gets $13M (release)
• Eye-disease biotech Potentia Pharma raises $12M (release)
• Sample-prep toolmaker Arcxis aims for $8M to $10M (VentureWire)
• Synvascular names Drew Hoffman as CEO (VentureWire)
• ArtusLabs gets $2.6M for life-science software and services (release)
• Cancer-drug maker Inotek loses CEO, Genentech partnership (release)
• GTESS, health-plan IT startup, names James Bradley CEO (release)
• Antibiotic developer Tetraphase Pharma names Guy MacDonald CEO (release)

Stemline Therapeutics, cancer stem-cell startup, gets $13M – New York-based Stemline Therapeutics, a biotech focused on new cancer treatments, raised $12.5 million in a funding round. Healthcare funds managed by Pequot Capital Management provided the funding.

Stemline is one of several companies that hope to attack cancer by taking aim at cancer “stem cells,” which are thought to give rise to tumors the same way embryonic stem cells develop into the body’s 200+ types of tissue. One theory holds that conventional cancer chemotherapy often fails because while it can kill huge numbers of tumor cells, it tends to miss the stem cells that can migrate through the body and spark metastatic tumor growth.

Stemline already has one experimental drug against acute myeloid leukemia in early stage clinical trials, although it licensed that drug from the Texas A&M Health Science Center rather than discovering the molecule itself. The startup reports eight other drug candidates at an earlier stage of development.

Stemline has so far been overshadowed by the much flashier OncoMed, another cancer stem-cell startup that  last December struck a partnership with GlaxoSmithKline potentially worth $1.4 billion. It’s not clear, though, whether OncoMed has actually begun clinical trials of its leading drug candidate yet.

Eye-disease biotech Potentia Pharma raises $12M – Potentia Pharmaceuticals, a Louisville, Ky., biotech focused on eye diseases of the elderly, raised $12 million in an unspecified funding round. Backers include HealthCare Ventures and MASA Life Science Ventures.

Potentia hopes to treat a blinding disorder known as age-related macular degeneration by reducing inflammation. Specifically, the startup’s lead drug candidate, POT-4, inhibits the complement system, an arm of the body’s immune defenses that may be responsible for much of the damage associated with AMD.

Sample-prep toolmaker Arcxis aims for $8M to $10M – Pleasanton, Calif.-based Arcxis Biotechnologies, a maker of systems that prepare biological samples for analysis, hopes to raise $8 million to $10 million in a second funding round, VentureWire reports. The company raised $6.5 million in its first funding round, which took place in three installments from August 2006 through February 2008.

CORRECTION: An earlier version of this item incorrectly stated that Arcxis raised $11.1 million in February and wrongly attributed that fact to VentureWire. Arcxis CEO Howard Goldstein emailed me with the correct numbers.