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	<title>VentureBeat &#187; antisense drugs</title>
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		<title>VentureBeat &#187; antisense drugs</title>
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		<title>Life sciences briefing: Friday, Nov. 9, 2007</title>
		<link>http://venturebeat.com/2007/11/09/life-sciences-briefing-friday-nov-9-2007/</link>
		<comments>http://venturebeat.com/2007/11/09/life-sciences-briefing-friday-nov-9-2007/#comments</comments>
		<pubDate>Fri, 09 Nov 2007 15:03:39 +0000</pubDate>
		<dc:creator>David P. Hamilton</dc:creator>
				<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[antisense drugs]]></category>
		<category><![CDATA[biotechnology]]></category>
		<category><![CDATA[cancer]]></category>
		<category><![CDATA[deal]]></category>
		<category><![CDATA[infectious disease]]></category>
		<category><![CDATA[polyclonal antibodies]]></category>

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		<description><![CDATA[<p><em><strong>Featured companies:</strong> Antisense Pharma, Arteriocyte, Excelimmune, Fluxion Biosciences</em></p>
<p><strong>UPDATED:</strong> Expanded items on Antisense Pharma, Arteriocyte, and Excelimmune.</p>
<p><strong>Antisense Pharma raises €27M for cancer drugs &#8212; </strong>Munich&#8217;s Antisense Pharma, a biotech developing gene-silencing drugs against cancer, raised €27 million ($38 million) &#8230;</p><img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=venturebeat.com&amp;blog=342986&amp;post=54672&amp;subd=venturebeat&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p><em><strong>Featured companies:</strong> Antisense Pharma, Arteriocyte, Excelimmune, Fluxion Biosciences</em></p>
<p><strong>UPDATED:</strong> Expanded items on Antisense Pharma, Arteriocyte, and Excelimmune.</p>
<p><a href="http://www.antisense-pharma.com/index_e.htm"href='http://venturebeat.files.wordpress.com/2007/11/antisense-pharma-logo.jpg' title='antisense-pharma-logo.jpg'><img src='http://venturebeat.files.wordpress.com/2007/11/antisense-pharma-logo.jpg' alt='antisense-pharma-logo.jpg' /></a><strong>Antisense Pharma raises €27M for cancer drugs &#8212; </strong>Munich&#8217;s <a  target="_blank">Antisense Pharma</a>, a biotech developing gene-silencing drugs against cancer, raised €27 million ($38 million) in a fourth funding round. The company&#8217;s PDF release is <a href="http://www.antisense-pharma.com/pdf/ap_pr_071108.pdf" target="_blank">here</a>.</p>
<p>MIG provided the funding, which the company said will support late-stage trials of its lead drug candidate, AP 12009, in brain cancer. AP 12009 is an &#8220;<a href="http://en.wikipedia.org/wiki/Antisense_therapy" target="_blank">antisense</a>&#8221; drug, one that blocks the activity of malfunctioning genes. Although long a promising way of attacking a variety of diseases, only one antisense drug has ever been approved, and most scientists believe that it doesn&#8217;t actually work via gene silencing. Antisense Pharma, however, says that AP 12009 showed positive results in a mid-stage trial.</p>
<p><strong>Excelimmune raises $2M for cancer, infection antibodies &#8212; </strong>Cambridge, Mass.-based <a href="http://www.excelimmune.com/" target="_blank">ExcelImmune</a>, a biotech developing &#8220;polyclonal&#8221; antibodies for fighting cancer and infection, raised $2 million in a first funding round, <a href="http://professional.venturewire.com/story.asp?sid=NKNILQPHIHJ" target="_blank">VentureWire reports</a> (subscription required). Greenheart provided the funding.</p>
<p>Many top-selling biotech drugs these days are <a href="http://en.wikipedia.org/wiki/Monoclonal_antibody_therapy" target="_blank">monoclonal antibodies</a>, which are genetically engineered to bind to a single target, such as a surface protein on cancer cells. Excelimmune, by contrast, focuses on polyclonal antibodies &#8212; essentially a mix of different antibodies that bind to different targets. Polyclonal antibodies are a major part of the body&#8217;s immune system, but no one has ever successfully developed polyclonal-antibody drugs. The company said the new funding will allow it to develop new polyclonal antibodies against an unspecified target, and that it will raise a second round next year to forward a candidate into animal tests.</p>
<p><a href="http://www.arteriocyte.com"href='http://venturebeat.files.wordpress.com/2007/11/arteriocyte-logo.jpg' title='arteriocyte-logo.jpg'><img src='http://venturebeat.files.wordpress.com/2007/11/arteriocyte-logo.jpg' alt='arteriocyte-logo.jpg' /></a><strong>Arteriocyte acquires product, forms partnership with Medtronic &#8212; </strong><a  target="_blank">Arteriocyte</a>, a Cleveland medical-device maker, struck a partnership with <a href="http://www.medtronic.com" target="_blank">Medtronic</a> that includes the acquisition of Medtronics&#8217; Magellan platelet business. The release is <a href="http://home.businesswire.com/portal/site/google/index.jsp?ndmViewId=news_view&amp;newsId=20071108006200&amp;newsLang=en" target="_blank">here</a>.</p>
<p><strong>OTHER HEADLINES OF NOTE:</strong></p>
<ul>
<li> Tool developer Fluxion Biosciences raises $6.9M <em>(PE Hub)</em></li>
</ul>
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