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Posts Tagged ‘co:Novacardia’

dollar-shadow1.jpg(UPDATED: See below.)

It’s been a long, barren summer for biotech IPOs, but ImaRx, the blood-clot company we featured here, finally managed to bull its way into the public markets. The company, which withdrew an earlier $75 million IPO and lowered its offering price on the current one, finally finally priced its IPO at its most recent target of $5 a share, selling three million shares for an anemic take of $15 million, excepting fees and possible overallotment sales.

That makes ImaRx the first biotech to make it to the public markets via an IPO in almost two months. The slowdown hasn’t stopped companies from filing — yesterday Archemix joined the list, and the day before brought us Cumberland Pharmaceuticals setting its offering price. Still, the backlog is building: Over at Signals Magazine, Jennifer van Brunt counts 12 outstanding IPO filings (13, actually, but only because she still lists NovaCardia, which which Merck bought out yesterday), the oldest of which — Light Sciences Oncology — has been at the starting line for over a year.

Much of the holdup reflects the fact that most of the biotechs that have gone public this year haven’t done well at all in the market. Response Genetics, for instance, went public on June 4, and has since fallen 13 percent. Jazz Pharmaceuticals, which we hazed here, here and here, lowered its offering price several times and is still down 20 percent. Amicus Therapeutics, which actually has an interesting technology, is down 23 percent. (Stock data courtesy of Renaissance Capital’s IPOHome.)

And so it goes, right down the line. Of the 17 biotech IPOs this year, only six — Sirtris Pharmaceuticals, Biodel, Pharmasset, Orexigen Therapeutics, Tongjitang Chinese Medicines, Optimer Pharmaceuticals — are trading above their offering price. Biotech investors are used to long odds, but at the moment, it’s hard to blame them for being a bit standoffish where new offerings are concerned. They’ll soon get a chance to test their mettle again, as the next few weeks are expected to bring Sucampo Pharmaceuticals and Cumberland Pharmaceuticals to the gate.

UPDATE: This item, which began life as a brief notice of the ImaRx IPO pricing, has morphed into a fuller take on the miserable state of the biotech IPO market.

UPDATE REDUX: So far, the odds of ImaRx breaking the IPO slump are looking pretty long. At about 10:45 a.m. Pacific time, the stock is trading down at $4.75, down five percent.

FINAL UPDATE: ImaRx closed its first day at $4.79, down 4.2 percent.

San Diego’s NovaCardia, a developer of drugs for cardiovascular disease, agreed to sell itself to Merck for $350 million.

The specialty pharmaceutical company has in-licensed two drugs from other drug makers, one to treat kidney problems in heart failure patients and another for atrial fibrillation. The heart-failure drug, KW-3902, should enter a late-stage trial this year; the atrial-fibrillation drug, meanwhile, is slated to enter mid-stage trials this year.

Actually, I take that back — KW-3902 has already completed one “pilot” late-stage trial, which is intended to establish the dose for three later trials that the company apparently hopes to present together in order to win FDA approval. It’s kind of unusual to still be establishing the proper dose this late in the process, and the FDA often looks askance at multiple trials if the company intends to try to make some sort of combined analysis. But I guess Merck is satisfied if they’re willing to pay top dollar for the company.

NovaCardia had filed for an $86.3 million IPO in March, after rejecting acquisition offers the previous year.

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