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Posts Tagged ‘genetic-genealogy’

t-giving-dinner.jpgWelcome back, American readers, from what we hope was a long and leftover-filled weekend. The news was slow, but here are a few stories you might have missed while still in your post-dinner food coma.

Frustrated by your teenager? Scan his brain — Actually, that probably wouldn’t help, although Arthur Toga has given it a try. Sort of. Toga, director of UCLA’s Laboratory for Neuro Imaging, has scanned the brain of his daughter Elizabeth ’s every year or so since she was six. The results of those scans, plus similar scans of Toga’s other two children, have produced one of the longest chronological sequences of brain development ever attempted. That and other work have produced some fascinating findings on the way child and adolescent brains develop, “transforming our understanding of what it means to come of age,” WSJ science columnist Robert Lee Hotz wrote in his Friday column. Unfortunately, as Toga himself attests, knowing more about your teen’s neural development doesn’t necessarily help you deal with adolescent rebellion.

Gates takes on genetic genealogy — Harvard scholar Henry Louis Gates, that is, who recently launched his own DNA-ancestry company, African DNA, after he became convinced that existing firms that claim to help African-Americans trace their country of origin were potentially misleading customers. An NYT story yesterday uses Gates’ experience to expound on the limitations and potential pitfalls involved in genetic genealogy, a subject we touched on here. As it turns out, however, the WSJ wrote substantially the same story a week earlier, which you can check out here (subscription required).

Healthcare economics 101 — The NYT editorializes on the high cost of U.S. healthcare in a lengthy piece, one that touches upon many of the usual suspects — patient demand for the latest, most expensive treatments, the overspecialization of the medical profession, perverse insurance incentives and high overhead costs associated with the fragmented and inefficient insurance industry — that we’ve noted in occasional pieces (here and here, for instance). The NYT’s proposed solutions, however, are a real mixed bag. More evidence-based medicine to ensure that drugs, devices and surgical procedures actually work is certainly a good idea, as would be wider deployment of IT and electronic medical records. It’s far from clear exactly what the NYT editorial board is expecting from the greater use of “managed care,” which particularly in its for-profit incarnation became a synonym for extracting greater investor returns at the expense of patient care.

And finally the editorial simply dissolves into incoherence. It favors letting Medicare negotiate lower drug prices, for instance, but doubts that doing so would produce big savings. So why bother? Paying doctors closer to what they earn in other countries — far less than the U.S., that is — would save money, but might be politically impossible. So is it part of the solution or not? Consumer-driven healthcare could reduce what people spend on unnecessary care — but they might also cut necessary care. And so on. Ultimately, the paper’s august editors conclude that there is “no silver bullet” for the problem, and that a “wide range of contributing factors needs to be tackled simultaneously.” While that’s almost certainly true, the NYT has managed to turn a challenging and timely subject into an object lesson on how not to write a convincing editorial. It might as well have been titled: “Confused about healthcare costs? So are we.”

Healthcare economics 201 — Meanwhile, an NYT news story brought the surprising news that the Medicare “doughnut hole” — a big financial gap in the program’s prescription-drug coverage — may actually have a silver lining by encouraging wider use of generic drugs. Similarly, Rite-Aid drugstores have started selling a genetic paternity kit made by Sorenson Genomics, and psychiatrist Daniel Carlat writes in the NYT Magazine about how he came to grips with the often-subtle influence wielded by pharmaceutical drug reps.

dna-tree.gifNo question about it, genetic genealogy — the hobby of using genetic tests to trace your ancestry and, in some cases, to locate previously unknown relatives — is hot these days. Today, of course, brought the news that Ancestry.com, a genealogy Web site that lets users construct family trees and pore over digitized versions of old census records or ship-passenger manifests, is launching a DNA Ancestry service as well. (Matt covered that in his story this morning over at VentureBeat proper.)

But the Ancestry.com move is really just the latest sign of a growing groundswell of enthusiasm — and, of course, hype — over new ways to buttress old-fashioned genealogy research with what seems to be cold, hard science. DNA Direct, which sells various medical genetic tests directly to consumers, just began offering genealogy and “ethnicity” tests as well, “in response to customer requests.” Startups like 23andMe plan to make genealogy searches and genome-based “social networking” a key part of their business (see our coverage here and here). 60 Minutes just ran a lengthy segment on genetic genealogy that purported to puncture some of the hype in the field (much to the dismay of some).

There’s no particular harm in any of this that I can see, which is a good thing given that I’m not sure what anyone could do about it if there was. (Again, the technology is getting ever cheaper and more available, so this train is pretty much leaving the station whether we like it or not.) Like anything else, of course, you should probably have a good sense of what you’re getting into before you start forking over hundreds of dollars for genetics tests. It’s important to remember that the tests often only suggest relatedness without really proving it, particularly where distant relatives are concerned. And of course anyone sending in a cheek swab or a saliva sample for a genetic test should be braced for the possibility of an unexpected family surprise or two, particularly once you begin comparing your genes with those of your (purported) relatives.

Mostly, in fact, the explosion of interest in genetic genealogy strikes me as an interesting example of what happens when a new technology — here, relatively cheap and available genetic tests — that appears to offer rigor and certainty meets a social phenomenon such as genealogy (the U.K.’s Guardian newspaper claims tracing your roots is the second most popular hobby in the U.S., after gardening). Without question, there will be some hurt feelings and deflated hopes as people realize that genetic testing has its limitations, too.

It’s also a nice illustration of the sort of weirdness we’re all going to face as our genetic information becomes more transparent to us and forces us to redraw many mental categories that don’t map particularly well onto the genome. The Guardian, for instance, recently ran this great story that looked into what genetic testing says about our sense of identity, particularly when the tests turn up unexpected results related to ethnicity or paternity.

Also, as I’ve noted before, there’s also the fact that your DNA probably isn’t anywhere near as private as you’d like to think, given the fact that you shed DNA-containing hair and skin cells pretty much wherever you go. That notion was underscored by this creepy story from the NYT back in April about DNA scavengers who, by hook or by crook, aim to get and test genetic samples from people they think might be related to them. And at that, I’m pretty sure we’re still only just scratching the surface of other changes that are in store for us.

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