VentureBeat

Featured companies: Cerus, LabNow, Reliant Pharmaceuticals

UPDATED: Expanded items on Reliant Pharmaceuticals and Cerus.

GSK acquires Reliant Pharma for $1.65 billion — And then there were none. Reliant Pharmaceuticals, a Liberty Corner, N.J., specialty pharma that filed for an initial offering back in August, has instead decided to sell itself to GlaxoSmithKline for the eye-popping sum of $1.65 billion. The release is here. The acquisition news comes just days after doppelganger Reliant Technologies abandoned its own IPO bid (see our coverage here).

Although that sum is pretty large, it’s a mere 18 percent premium over the $1.4 billion market capitalization Reliant Pharma would have fetched had it priced at the top of its expected per-share range at $27. As we noted earlier — see our previous coverage here and here — Reliant is kind of a mixed bag insofar as specialty pharma companies go. It yanked an earlier attempt to go public back in 2005, and remains unprofitable despite pulling down $360 million in revenue for the first nine months of this year.

Reliant sells four unrelated cardiovascular drugs, the most significant of which is Lovaza, an omega-3 fatty-acid pill for people with high levels of triglycerides. Although GSK touts it as the only omega-3 supplement “clinically proven” to reduce triglyceride levels in adults with high triglycerides, it’s kind of hard to imagine that this really sets it apart from all the other omega-3 supplements you can find on the shelves of your local drugstore or supermarket. (Here at Chez Hamilton, we take the Costco house brand fish-oil supplement, which is plenty high in omega-3s, even if it hasn’t been “clinically proven” to reduce triglycerides. For Reliant’s song-and-dance as to why Lovaza is superior to fish-oil supplements, click here.) Yet Lovaza is exactly what GSK touts as its reason for dumping a billion-plus bucks of its shareholders’ money on this company.

Don’t think that Reliant has a secret weapon in its labs, either –because, you know, Reliant doesn’t really have labs. Like most specialty pharmas, it’s a bottom-feeder, acquiring drugs that no one else wants or can find a good use for. That can be a perfectly good business, and there’s no question that Reliant’s shareholders have done well in this transaction, but no one should mistake what companies like Reliant do for actual innovation. As for why GSK thinks this company is so valuable — well, chalk it up to desperation and the madness of crowds.

Cerus spins out venture-backed immunotherapy unit — Concord, Calif.-based Cerus is spinning off its cancer-vaccine program into a new, and as-yet unnamed, venture-backed company. The release is here.

Cerus will focus its own efforts on its Intercept blood-safety system, which theoretically neutralizes viral and bacterial pathogens in donated blood using a small molecule that binds to DNA or RNA and “cross-links” the molecules, rendering them incapable of replication. Intercept has had tough sledding in the U.S., but is approved in Europe.

Cerus didn’t identify backers of the new immunotherapy company, although it said David Cook and Thomas Dubensky have joined it as CEO and chief scientific officer, respectively. Cerus will retain a 16 percent interest in the new company, and is eligible for milestone payments of more than $90 million, plus royalties, should any of the new company’s vaccines pay off.

OTHER HEADLINES OF NOTE:

• Cerus spins out venture-backed immunotherapy unit (release)
• LabNow receives $20M for AIDS blood-analysis device (release)

Featured companies: Ablynx, Avant Immunotherapeutics, BioForm Medical, Celldex Therapeutics, Genomas, High-Throughput Genomics, Orchid Cellmark, ReliaGene Technologies, SarCode, TransMolecular, VisEn Medical

UPDATED: Expanded items on SarCode, Celldex/Avant and Ablynx.
UPDATE REDUX: Added items on BioForm Medical, High-Throughput Genomics and Orchid Cellmark/ReliaGene.

San Francisco’s SarCode draws down $7M for inflammation drugs — The two-year-old startup drew down $7 million as part of a $25 million first funding round the company arranged last December, VentureWire reports (subscription required). Investors in that round included Alta Partners and Clarus Ventures. The company’s post-investment valuation was $30 million in December.

SarCode is focused on developing new treatments for inflammation using technology it licensed from Sunesis Pharmaceuticals in January. The company can still draw another $13 million from its first round, and anticipates that existing funding will carry it through the end of 2009.

Cosmetic-surgery product maker BioForm sets IPO range, aims for $127M — San Mateo, Calif.-based BioForm Medical, a developer of skin fillers and other cosmetic-procedure products, set its sights on an IPO that could raise up to $126.5 million. BioForm now aims to sell as many as 11.5 million shares at a price of $9 to $11 apiece. Should it come in at the high end of that range, the offering would value the company at almost $500 million.

See our previous coverage of BioForm, which sometimes touts itself as more of a medical-device company than one focused on “medical aesthetics,” in the first item here. The company’s main customers are plastic surgeons and dermatologists.

Celldex goes public with $67M Avant acquisition — Privately held Celldex Therapeutics acquired a majority stake in publicly traded Avant Immunotherapeutics for $66.7 million in stock. The release is here.

The deal effectively takes Celldex public via a form of reverse merger. Although the combined company will be known as Avant, Celldex shareholders will own 58 percent of it. Avant’s current CEO, Una Ryan, will remain in that position in the combined company, which will be worth an estimated $115 million following the merger. The new Avant will pursue a number of immune-related treatments for cancer, infectious disease and autoimmune disease.

High-Throughput Genomics raises $10M for gene-expression tools — Tuscon’s High-Throughput Genomics, a biotech focused on tools that measure gene activity, raised $10 million in a third funding round. Investors included Merck Capital Ventures, Solstice Capital, Valley Ventures and Arcturus Capital.

HTS, founded a decade ago as a subsidiary of a combinatorial-chemistry company called Systems Integration Drug Discovery Company, spun out as an independent company in 2001. The company provides tools that let researchers study the activity of genes and proteins in laboratory samples.

Ablynx aims at €99.2 million IPO for “mini-antibodies” from llama DNA — Belgium’s Ablynx, a biotech focused on developing new therapies using miniature antibody molecules derived from llama DNA, said it hopes to raise as much as €99.2 million ($141.5 million) in an IPO. (Its release is here.)

The offering will be launched on Eurolist by Euronext Brussels. You can find our previous coverage of the company here and here.

OTHER HEADLINES OF NOTE:

• DNA-testing co. Orchid Cellmark acquires ReliaGene Technologies for $8.6M (release)
• VisEn Medical raises $7.5M for imaging (PE Hub)
• Genomas pulls in $2.5M for “DNA-guided medicine” (PE Hub)
• TransMolecular names Nicholas Nicolaides chairman (release)

Featured companies: Ablynx, Cardiosolutions, Carigent Thereapeutics, Elusys, Genome Corp., GlobeImmune, Novazone, Targanta Therapeutics, Waterfront Media

UPDATED at 5:45am on 9/27/07

GlobeImmune raises $41M for immune-system therapies — GlobeImmune, a Louisville, Colo., biotech focused on new forms of immunotherapy to treat viral infections and cancer, raised $41.2 million in a third funding round. Investors included Wexford Capital, Celgene, the Mellon Family Investment Company, the Richard King Mellon Foundation, Eminent Venture Capital, Boston Life Science Venture, WRF Capital, HealthCare Ventures, Morgenthaler Ventures, Sequel Venture Partners, Lilly Ventures, Medica Venture Partners, Adams Street Partners, Biogen Idec, Pac-Link Bioventures, China Investment and Development, Yasuda Enterprise Development, Partners Healthcare, and GC&H Investments.

GlobeImmune’s experimental drugs are based on genetically engineered yeast cells, which have been altered to produce proteins that stimulate the immune system to attack diseased cells. The company’s lead product targets hepatitis C, and has completed early-stage human trials. Another drug is intended for use in pancreatic cancer.

Waterfront Media pulls in $25M for online health info — New York’s Waterfront Media, which bills itself as the largest privately held provider of online health information, raised $25 million in a fourth round of funding. Investors included Scale Venture Partners, Foundation Capital, Rho Ventures, Time Warner Ventures, BEV Capital, and Neocarta Ventures.

Waterfront said it will use the funds to expand its Everyday Health Network, a health-information portal, and to make acquisitions in the goal of becoming the “number one health destination” on the Web.

Novazone seeks $20M for food-safety tech — Novazone, a Livermore, Calif., developer of food-safety technology, is looking to raise $20 million in a third funding round, VentureWire reports (subscription required). Novazone is developing an ozone-based disinfectant for food and water purification. The company previously raised $7 million in 2006 from Chrysalix Energy, Foundation Capital and Grauer Capital.

Cardiosolutions raises $7M for heart device — Stoughton, Mass.-based Cardiosolutions, a medical-device maker focused on minimally invasive repairs to the heart’s mitral valve, raised $7 million in a first funding round. BioVentures Investors led the round.

The company’s device is intended to restore function to the valve that separates the two left chambers of the heart without open-heart surgery. Cardiosolutions was founded in 2006 by STD Med, a Stoughton-based medical-technology firm.

Elusys wins $12M contract for anthrax treatment — Pine Brook, N.J.-based Elusys, a biotech focused on antibody-based treatments for infectious disease, won a $12 million federal contract that will support development of its anthrax treatment Anthim. That treatment targets the so-called “protective antigen” component of anthrax, theoretically blocking the bacteria’s ability to produce fatal levels of toxin.

Ablynx wins €1.9M grant for miniature antibodies — Belgium’s Ablynx, a biotech working to devise new therapies using miniature antibody molecules, received a €1.9 million ($2.6 million) grant from the Institute for the Promotion of Innovation by Science and Technology in Flanders. The company said the funding would allow it to pursue new uses for its “nanobodies” and to expand its intellectual-property portfolio.

Genome Corp. raises $250K for new sequencing technology — Providence, R.I.-based Genome Corp. raised $250,000 in seed financing to extend development of a new high-speed DNA sequencing technology. The Slater Technology Fund provided the financing.

Nanotech-drug developer Carigent Therapeutics raises seed funding — Yale spinout Carigent Therapeutics, a New Haven, Conn., biotech working on a nanoparticle-based drug technology, raised an undisclosed amount of seed funding, VentureWire reports. Saint Simeon Marketing e Investimentos provided the funding in May.

The idea is that engineered nanoparticles can specifically target particular proteins, theoretically making them ideal “carriers” for other drug molecules that attack cancer, infectious pathogens or other other disease-related substances. The company has also secured $250,000 in grants from the National Cancer Institute and the National Science Foundation, and plans to target cancer with its first product, it told VentureWire.

Antibiotic maker Targanta sets IPO price range — Cambridge, Mass.-based antibiotic developer Targanta Therapeutics said it now hopes to raise up to $92.6 million in an IPO by selling shares at a price of $12 to $14 apiece. Targanta has previously expected to pull in $86.3 million; I wrote about some of the risks inherent in the company’s plans to win FDA approval for an in-licenced antibiotic called oritavancin that it hasn’t even tested itself here.

So far, Targanta seems to have managed to assure investors that it can overcome those challenges, which include some potentially strong competition from a variety of sources. Its offering will still serve as a good test of the strength of the biotech IPO market, which has been iffy for well over a year.