VentureBeat

TODAY’S HEADLINES:

• Affinergy gets $3M in grants for biological “linkers” (release)
• Specialty pharma EUSA raises $50M, spends $23M for public biotech Cytogen (release)
• Calderome takes in $12M for cancer diagnostics (peHUB)
• Pulse Health raises $2M for handheld free-radical device (release)
  
• LifeMasters takes in $15M for wellness, disease-management programs (release)
• Dubai Techno Park launched $300MVC fund for life sciences, other sectors (release)

Affinergy gets $3M in grants for biological “linkers” – Affinergy, a Duke University spinout in Research Triangle Park, N.C., received grants worth more than $3 milllion to support development of biological “linker” molecules with potential uses in coatings for medical devices and the development of new therapeutics. The grants were awarded by the federal National Institutes of Health through its small-business innovation research program.

The startup is developing biological molecules that can selectively bind various substances to particular surfaces. Such linkage molecules could, for instance, attach healing growth factors to surgical meshes or other implanted biomaterials or help target drugs at particular cell-surface proteins. The company hasn’t described its goals in much detail, although it said one of the grants is for work aimed at accelerating a patient’s natural healing process.

Specialty pharma EUSA raises $50M, spends $23M for public biotech Cytogen – In today’s man-bites-dog news, the venture-backed specialty pharma EUSA Pharma agreed to acquire the publicly traded biotech Cytogen for $22.6 million. The EUSA release is here; Cytogen has its own release here.

In one sense, the news isn’t terribly surprising, as Cytogen effectively put itself up for sale last November when it announced it was “reviewing strategic alternatives.” The twist here is that EUSA is taking the biotech private — a sign of just how far Cytogen’s fortunes have fallen since the heady days of the 1999-2000 biotech bubble, when its stock almost touched $200 a share. EUSA, which has offices in Doylestown, Pa., and Oxford, England, is offering 62 cents a share, a 35 percent premium over Cytogen’s closing price yesterday of 46 cents.

On the business front, however, it’s hard to say that the combination will be much more exciting than either company has been individually. Both EUSA and Cytogen traffic in a range of largely unrelated drugs for pain and cancer treatment.

EUSA raised $50 million to finance the cash transaction, for working capital and to restructure Cytogen. Investors included TVM Capital, Essex Woodlands, 3i, Goldman Sachs, Advent Venture Partners, SV Life Sciences, NeoMed and NovaQuest.

Calderome takes in $12M for cancer diagnostics – Calderome (no Web site), a South San Francisco, Calif., developer of cancer diagnostics, has taken in $11.9 million of a $23 million first funding round, peHUB reports. (peHUB identifies the company as located in Menlo Park, Calif., but two Calderome job postings on Biospace indicate its headquarters are actually in South San Francisco.)

In fact, I’m loving job listings at the moment, because the company also advertised one of those positions on Craigslist here. According to that listing:

Calderome, Inc. is an early stage cancer diagnostics company addressing the emerging opportunities in personalized medicine. The Company’s strategic vision is to develop a novel molecular cytology approach to improve the diagnosis of cancer, saving patients thousands of unnecessary surgeries every year. The company has spent the last year validating its business model with key stakeholders: physicians, patients and payers and has recently closed a significant round of private equity financing with premier venture capital investors….

In other words, it sounds very much like the company is developing a cell-based diagnostic, possibly involving a test that can pick up tumor cells that circulate in the bloodstream, that can help diagnose cancer without the need for invasive biopsies. That’s merely speculation, however.

Investors in the round include Kleiner Perkins Caufield & Byers, TPG Biotechnology Partners and Versant Ventures.

TODAY’S HEADLINES:

• Ulthera receives $23M for cosmetic ultrasound devices (release)
• Senexis raises £2.9M for Alzheimer’s drugs (PDF release)
• Elixir Pharma postpones IPO (IPO Home)
• Cancer Therapeutics names Randall Riggs as CEO (release)

Ulthera receives $23M for cosmetic ultrasound devices — Ulthera, a Mesa, Ariz., startup developing ultrasound systems for cosmetic procedures, raised $22.5 million in a second funding round. Investors included New Enterprise Associates and 3i.

Ulthera, whose Web site is still a stub, aims to use its ultrasound devices for face lifts and “skin rejuvenation.” The company says the ultrasound can penetrate and remove — “microabrades,” in its terminology — skin tissue that is several layers deep without disturbing the surface, or epidemis. Deeper treatment supposedly triggers a “natural healing effect,” which Ulthera’s CEO claims will lead to a “gradual lifting and tightening of skin tissue in and around the face.”

The product can produce ultrasound images of the area to be treated as well. Ulthera has regulatory clearance to sell its device in Europe and expects FDA approval soon as well. The company will use the funds it raised for global commercialization, product development and to conduct additional trials to expand the use of its technology.

Senexis raises £2.9M for Alzheimer’s drugs — Senexis, a Cambridge, U.K., biotech working on drugs for Alzheimer’s disease and other conditions related to aging, received £2.9 million ($5.7 million) from the Wellcome Trust. The funding came from the Wellcome’s “Seeding Drug Discovery” program, and and augments £700,000 Senexis raised last year from BTG, a London specialty pharma. BTG and the Wellcome had previously invested £2.4 million in Senexis.

The company is developing small-molecule drugs intended to prevent the misfolding of amyloid proteins, which clump together in plaques around nerve fibers. Many scientists believe that these amyloid plaques cause inflammation that ultimately kills nerve and brain cells in Alzheimer’s patients, although dissenters still argue that plaques may be a distraction or even a defensive reaction to the disease. At this point, no one can say for certain exactly what causes the disease.

Still, most Alzheimer’s drugs now under development target the clumping amyloid proteins, and Senexis is no exception. One of its two lead candidates is a small molecule designed to inhibit the misfolding and aggregation of amyloid proteins in Alzheimer’s patients. The other is intended to tamp down brain inflammation. Both are still in animal testing. Senexis also hopes to treat diabetes by inhibiting aggregation of an amyloid protein that the company appears not to have identified.

Elixir Pharma postpones IPO — Elixir Pharmaceuticals, a Cambridge, Mass., biotech focused on anti-aging and obesity drugs, postponed its IPO. The company had most recently planned to raise as much as $92 million in its offering.

It’s not entirely clear why Elixir, which I figured would follow in the footsteps of Sirtris Pharmaceuticals‘ successful IPO (our coverage here), chose to delay the offering — which is almost always code for pulling it entirely. One possible reason might be that Elixir co-founder Leonard Guarente, a MIT professor sometimes tipped as a future Nobel laureate, decamped from Elixir for Sirtris in November.

You can see our previous coverage of Elixir here and here.

Konarka, yet another company experimenting with new-fangled technology to produce more efficient solar cells, hasn’t been able to articulate a clear business strategy in the six years since it started.

However, solar technology is hot, and the company has raised $45 million more in capital to give it more time to keep trying. It has now raised more than $100 million.

Like several other start-ups, the Lowell, Mass. company has been using non-silicon material to produce a more flexible thin-film solar cell to convert light into energy. However, it has continued to dabble on a number of solar projects, while its competitors have remained laser-focused on producing a producing a workable cell for the roofs of large buildings and other expansive areas. Even with focus, those other companies have been delayed.

The financing was led by Toronto investment firm, Mackenzie Financial, along with Good Energies. Other investors were Pegasus Capital and existing investors Draper Fisher Jurvetson, Asenqua Ventures, New Enterprise Associates (NEA) and 3i.

Konarka is using a plastic, or “polymer” for its technology, and is testing it in a variety of areas, including portable and consumer products such as powering PDAs or recharging batteries on the battlefield, and in various parts of housing (windows, for example) other than rooftops. The products aren’t expected to hit the market until next year.

Other participating current investors include Vanguard Ventures, Chevron, Massachusetts Green Energy Fund, NGEN Partners, Angeleno Group and Asenqua Ventures.

Here’s the latest action (updated):

Airborne mash-up: lawn chair travels 193 miles –Oregon resident Kent Couch tried to fly to Idaho last weekend — in an apparatus made out of his lawn chair carried by 105 large helium balloons. He carried instruments to measure altitude and speed, and also a parachute. He didn’t make it, though. (Image courtesy of AP)

More adult supervision at Facebook — Chamath Palihapitiya, a former AOL executive turned venture capital investor at the Mayfield Fund, will be joining the company as VP of product marketing and operations. Known for helping to turn around AOL’s instant-messaging division, his job now will include helping the company to figure out how to make more money.

Rumors have emerged that Facebook wants to public, and so filling out senior ranks is important. Facebook now says it has 30 million active users. It is reportedly making $30 million annually from $150 in revenue. We’ve heard a big portion of this comes from Microsoft payments for banner ads on the site. Palihapitiya caused controversy earlier this year, when he commented in a French video about a “white male circle of insiders” running Silicon Valley (our coverage here). Facebook also recently hired a new chief financial officer, Mike Sheridan, formerly CFO of video game publisher IGN Entertainment Inc.

MSN search engine market share actually grows — After steady decline, it has grown of late, driven by online games like Chicktionary, Compete reports; analyst Steve Willis has the full explanation:

A good portion of the additional Live searches are coming from the Live Search Club, where you can apparently play games for points which you can redeem for fine Microsoft products. All of the games involve using Live’s search engine - to get the points, you have to search with Live.

Google brings Map mashups to its platform — Tomorrow, Google brings Map mashups of data from external sites like Zvents and ChicagoCrime.org to its own platform, Mashable reports.

Index Ventures and 3i launch Seedcamp in Europe — Details are here. Entrepreneurs apply with their “big ideas” before August 12 and the top 20 will be chosen to spend a week in London with industry professionals (VCs, lawyers, marketers, HR people, etc), and from there, the top 5 winners will be announced and they’ll receive 50,000 euros in funding and continued mentorship to get their businesses started.

Nielsen/NetRatings, a leading online-measurement service, scraps rankings based on page views — Instead, it will begin tracking how long visitors spend on Web sites. The move comes as page views lose their value in expressing a site’s importance. Many sites, such as Friendster, have boosted page views with simple networking features. Others, such as those using online video and new technologies such as Ajax, reduce page views.

AOL releases new test version of myAOL — It offers new personalized tools such as myPage, a personal dashboard offering access to content and applications from AOL and other sites; Mgnet, which lets users find new sites and information based on personal preferences; and Favorites, a feed reader that combines user feeds and bookmarks in one place.

Users of TiVo can order movies from Amazon.com directly from their TVs — Details here.

Intel Corp. invests $218.5 million in virtualization software maker VMware – The investment will give Intel ownership of about 2.5 percent of VMware’s outstanding shares after VMware completes its initial public offering. Details here.

Will the video start-ups ever stop coming? — United Talent Agency and advertising start-up Spot Runner have jointly created a company called 60Frames Entertainment to finance and distribute original professional videos online. 60Frames, of Los Angeles, has raised $3.5 million in funding from investors including Tudor Investment Corp. and the Pilot Group, and says it wants to provide higher quality videos than YouTube. Its videos will run a few minutes and cost “in the thousands, not hundreds of thousands” of dollars to produce, the NYT reports.

Talking of video sites, Revision3, another one, finally gets CEO — Recently departed PC World editor Jim Louderback will become CEO at video site Revision3, replacing interim chief exec, Jay Adelson NewTeeVee’s Liz Gannes reports.

Sequoia Capital, which recently invested in video site, Funny Or Die, now says there’s too much content — Roelof Botha, the Sequoia Capital partner who also invested in YouTube and Joost — video companies that only help to propagate more content — now says there’s so much information out there that it is overwhelming, and so you need humans to help (thus Sequoia has invested in Jason Calacanis’ human-assisted search engine, Mahalo). See video below, conducted by WSJ’s Kara Swisher (RSS readers will have to go to site):

Ning’s ridiculously large venture capital round — Ning, the company that provides tools for people to create their own social networks, co-founded by Netscape founder Marc Andreessen, has raised a whopping $44 million, on a reported $170 million pre-money valuation. That values the company at a mighty $214 million. Andreessen says on his blog the round was “orchestrated” by the wealthy family firm Allen & Co, of New York, and was led by Legg Mason of Baltimore, with a number of others participating. Andreessen is smart. Large East Coast firms are flush with cash, and are also somewhat removed from the valley, and so won’t realize just how competitive this market is. If you’re curious to know more about Allen & Co., here’s an impossibly long story in Fortune about the firm.

Digg released an application for the iPhone — The news ranking site’s founder Kevin Rosen announces it here.

A link-exchange network for Facebook apps — Developers of applications on Facebook’s platform can exchange links in order to get more attention and traffic, by using FbExchange. More details at GigaOm.

Hey!Spread, a video uploading service that delivers your videos to multiple sites — Upload your video to YouTube, MySpace, Google Video, Yahoo Videos, Dailymotion and Blip.tv all at the same time. (Techcrunch).

TwitterGram lets you deliver voice message on Twitter — It comes from Dave Winer, the Web guru who also created the RSS protocol. You can leave the message with a phone.

The mobile TV market is expected to have more than 130 million customers by 2011, according to Screen Digest.

So DiBcom, a France-based semiconductor-for-mobile-tv company has received another $27 million in funding from its many investors, this time adding French bank NATIXIS. The company says it will use the money to continue improving its TV-streaming technology, and to spread faster internationally to phones, laptops, cars and other devices around the world.

We’re speculating that the company timed this round with the recent news that the European Union’s regulatory agency, the European Commission, has decided to favor the DVB-H (Digitial Video Broadcasting - Handheld) system, which rivals Qualcomm’s MediaFlo and South Korea’s DMB (Digital Media Broadcasting) systems. The three offer rival ways to stream remote data onto devices, which is especially important for telecoms trying to expand their mobile offerings. In contrast with the US and other countries, the EU agency favors a single-standard approach to decide how best to deliver mobile TV.

DiBcom has had a string of semiconductor innovations based around DVB-H, beginning in 2005. It has landed deals with mobile carriers in Europe, and with a broad range of consumer electronics firms. The company also says it has over 300 mobile TV trials underway across the world.

There will be stiffer competition in the US. DVB-H is prominently supported here through the Mobile DTV Alliance, which includes Nokia, Motorola, Microsoft, Intel and Texas Instruments. AT&T, Sprint Nextel, and Verizon, however, are using Qualcomm MediaFLO standard. The third rival, DMB (Digital Multimedia Broadcasting), which was born out of a South Korean national IT project, is not as big in the US, but is also spreading around the world.

And mobile TV itself is still a risk. While it is fine for analysts to make their projections, the mobile TV market has yet to take off significantly. It’s unclear how many people are really wanting to watch full programming on their phones. Many may prefer user-generated content, like friends’ video clips. Indeed, as the parent company of DVH-H based Modeo said in a recent filing:

Modeo’s business has certain risk factors different from our core tower business, including an unproven business model, and may fail to operate successfully and produce results that are less than anticipated. In addition, Modeo’s business may require additional financing which may not be available.

Besides NATIXIS, investors include: 3i, Cipio Partners, Convergent Capital, Credit Agricole Private Equity, Intel Capital, Partech International, SGAM Alternative Investments, UMC Capital, and WI Harper.

Fabrik, a company that offer online storage and easy sharing of big files, has just closed a $24.9 million deal and added Ross Levinsohn, former President of Fox Interactive Media, to the board.

Its financing came primarily from 3i, with a small chunk from ComVentures.

As noted before, Fabrik competes in an increasingly crowded market, though their website reveals an effort to create a youthful brand (compare their site, for example, to YouSendIt, Box.net, and Omnidrive). Fabrik is now going after the consumer market, even as players like YouSendIt are going the other way, targeting professionals. Other related players include SoonR, Avvenu (see coverage here), and still more are listed here in Terence Pua’s piece about why storage will never quite be free.

Levinsohn, you’ll recall, spearheaded News Corporation’s plunge into the online world, overseeing, among other things, the development of Fox.com and the acquisition of MySpace, and his joining the board is indicative of Fabrik’s intention to push past the small business market and target consumers.

Also, unlike these other companies, Fabrik has expanded into hardware. Last February, they dropped $43M to buy SimpleTech, a major provider of external storage devices, (hard-drives, USB flash drives, etc). Until then, it had partnered with Seagate (makers of Maxtor). With hardware, it has also added Western Digital to its competition. Fabrik’s intention is to be the self-described “Apple of storage,” offering a line of hardware and software products whose components work best when used together.

Fabrik’s CEO Mike Cordano tells us his company was profitable before the infusion, but that it will allow them to expand their international efforts and diversify their offerings. What types of offerings these would be remains a secret for now.

The company told us late last year it had already raised $12 million in financing, and close to 90 percent of that is still in the bank, much of it coming from ComVentures. It has now raised a significant $36.9 million.