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CVRx, a Minneapolis-based developer of an implantable device for the control of high blood pressure, raised $65 million in a fourth round of funding that will support a “pivotal” clinical trial of the device. The round was led by Johnson & Johnson Development, and also included existing investors New Enterprise Associates, Thomas Weisel Healthcare Venture Partners, InterWest Partners, ABS Ventures, Frazier Healthcare Ventures and SightLine Partners. CVRx has so far raised a total of $125 million.

The company’s Rheos Baroreflex device is designed to stimulate the body’s own blood-pressure regulation system — known as the baroreflex — to control hypertension. It consists of an implantable pulse generator and two lead wires that are attached to the left and right carotid arteries. Using timed electrical stimulation, the device triggers the baroreflex, which in turn signals the brain to lower blood pressure throughout the body. This sort of “neuromodulation” approach is an increasingly hot area in medical-device development, although it remains largely unproven.

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Few are aware of the looming issue of coat hanger pollution. Yet there they are, lying in heaps, projecting up from overburdened landfills, their anonymous, identical tops crooked into a single a questioning pose: Why? Why so much hanger waste? Coming to the rescue is Hanger Network In-Home Media, which promotes biodegradable updates of [...]

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A new sort of virtualization is appearing in companies like ScaleMP, which turns the conventional notion of splitting one server into multiple virtual systems on its head. ScaleMP instead aggregates together multiple low-end systems to create a more powerful one. The technique can help with systems requiring large amounts of memory, and ScaleMP says [...]

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The Active Network, a San Diego, Calif.  sports community site, has raised $65 million in a fifth round of financing, according to PE Hub.
Canaan Partners led the deal, and was joined by fellow return backers like ESPN, ABS Ventures, North Bridge Venture Partners, Comdisco and Charles River Ventures.  New investors included Performance Equity and Tao [...]

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