VentureBeat

Featured companies: American Aerogel, Clinicient, Frazier Healthcare Ventures, Genome Diagnostics, RadPharm, RainDance Technologies, Vivacta

UPDATED: Expanded items on Vitae, RadPharm, Vivacta and Genome Diagnostics. Intelligent Bio-Systems is now covered in a standalone item here.

Vitae Pharma takes in $15M for blood pressure, diabetes drugs — Vitae Pharmaceuticals, a Fort Washington, Pa., biotech focused on new drugs for hypertension and metabolic disorders, raised $15 million in a fourth funding round, VentureWire reports (subscription required). Boehringer Ingelheim, which struck a major partnership with Vitae in mid-October (PDF link), provided the funding.

That partnership calls for the two companies to co-develop Vitae drug candidates that inhibit a protein called 11beta-HSD1, an enzyme that helps regulate the hormone cortisol. The drugs may be useful in treating diabetes, obesity and hypertension. B-I agreed to pay Vitae $36.5 million in cash, research funding and an at-the-time unspecified equity investment, as well as up to $300 million in potential milestone payments.

Vitae’s other major drug program involves compounds that inhibit the protein renin, which regulates blood pressure and vascular function. Renin inhibitors, which could be useful in treating hypertension, have been a white whale of sorts for the drug industry over the past 30 years (see, for instance, this somewhat technical discussion of the history here).

UK’s Vivacta draws in $12M for medical diagnostics — Vivacta, a U.K. medical-diagnostic company formerly known as PanOpSys, raised $12 million in a second funding round. Investors included AGF Private Equity, HBM BioVentures, Spark Ventures and Viking.

Vivacta is developing a fast, “point of care” diagnostic system intended to deliver laboratory-quality test readings from drawn blood in doctors’ offices or at a hospital bedside. The technology is based on a “piezoelectric” film coated with antibodies to particular blood proteins. Piezoelectric devices produce current when compressed, so theoretically this approach should allow a direct measurement of blood proteins by generating current proportional to the density of antibodies that capture any particular blood protein.

RadPharm gets $10M for medical-image reviews — RadPharm, a Princeton, N.J., provider of medical-image review services, raised $10 million in a second funding round. Investors include Siemens Venture Capital, Ampersand Ventures, Adams Street Partners and Tang Capital Management.

RadPharm essentially provides outsourced analysis of medical images ranging from CAT scans to X-rays for clinical trials, whose outcomes can hinge on the way those images are read and analyzed. Trials of cancer drugs, for instance, frequently look at whether tumors shrink, stabilize or grow, and determining that requires someone to look at actual patient X-rays or other images and decide what they actually show. RadPharm’s service provides “centralized, independent, blinded interpretation” of such scans.

Genome Diagnostics, cancer-test maker, aims for $1.6M — Genome Diagnostics, a Pasadena, Calif., developer of cancer diagnostic tests, has raised several hundred thousand dollars toward an anticipated $1.6 million first funding round, VentureWire reports. B.C. Capital of Israel and several individual investors provided the funds.

According to VentureWire, the company aims to produce a diagnostic test for prostate cancer based upon gene variations detected by sequencing a patient’s entire genome. That sounds unlikely on several levels, the first of which is that “whole-genome sequencing” — VentureWire’s description of what the company is doing — is still incredibly expensive, with an estimated cost of $100,000 or more.

It seems far more likely that the company will do a rough-and-ready genome scan that samples only several hundred thousand of the genome’s three billion DNA “letters” that are known to vary between individuals — at least, that is, unless Genome Diagnostics is betting that the cost of whole-genome sequencing will drop to the fabled $1,000 or so by the time it gets its product to market. And maybe that’s exactly what the company is doing, although that would mean that its initial testing costs are going to be extraordinarily high.

It’s also far from clear exactly what sort of prognostic information the company hopes to obtain from a genome scan of either type, since most genetic-association studies can only show increases or decreases in the probability of disease, and with such a margin of error that it’s difficult to see how that information could possibly serve a diagnostic purpose. I’ll try to circle back to the company in order to get a better idea of what they’re up to for a future post.

OTHER HEADLINES OF NOTE:

• Clinicient receives $5M for healthcare revenue-management software (release)
• Genome sequencer Intelligent Bio-Systems raises funding (VW)
• American Aerogel raises $3.2M for biopharma gels (VW)
• Frazier Healthcare Ventures raises $600M life-sciences fund (Seattle P-I)
• RainDance Technologies appoints Christopher McNary as CEO (release)

For years, technology to search for people has been neglected, compared to most parts of the Web. Until now, that is.

A wave of new entrants are making it much easier to find out everything about a person, from their job, to their personalities, their age and even where they live. Forget the privacy implications, the race is on.

LinkedIn, a social network for professionals, had the field to itself a few years ago. Sites like Friendster let you search for friends, but it wasn’t ordered for full-on people search.

Only over the past year or so has there been a frantic rush to offer more sophisticated people search. Facebook, for example, has emerged into a networking tool, and increasingly a place where people search for each other. Here’s the latest string of developments:

–ZoomInfo, one of the largest contacts site that lets you search a database of people and company profiles, will announce next Wednesday it will open to let developers build create applications on its platform. ZoomInfo is one of the more mature people search sites, but for while had remained relatively closed. The public API can be found here, http://developer.zoominfo.com (this will work next week) with more documentation. ZoomInfo has already worked with Amazon A9, Compete and Xing on this. For example, take a look at Compete’s profile on CNET, and you’ll see that it carries a widget on the right with more information provided by ZoomInfo.

– ZoomInfo now lets you look up full profiles at its site, and through widgets via its API; it merely limits the number of searches you can do on people. You have to pay to search high numbers of people, and to search by certain sub-category of occupation, for example. Related: ZoomInfo and a business networking site, Xing, announced a partnership to integrate their services in June, and there’s news next week on that front too. Xing adds the networking features that ZoomInfo hadn’t had until now.

– Viadeo, is a French-based company that lets you add a profile and then search for contacts according to industry they work in, or any other number of variables. It also lets you search for jobs. We registered, tried it out and found it functional. Each person tags themselves according to subjects they’re interested in, and people can get in touch with each other. The company is similar to LinkedIn. It just raised €5 million in funding (see Mashable) from its existing backers AGF Private Equity and Ventech. It has more than 1.3 million members. It now operates in several European countries, and is expanding into Chinese via a partnership with Tianji, a Chinese social network. (screenshot at bottom)

– Yahoo China has just released a new version of its search, Yahoo.cn, that includes a people search, though it’s focused on celebrities. Yahoo uses information extraction technology and semantic analysis to create a Flash-based map of relationships, along with explanations of why they are related to and the sources of the information. China Web 2.0 provides an example of Jack Ma. Another Chinese company, Koowo, reportedly got $5.5 million for among other things, a similar mapping of Chinese stars. However, the downside is that these offerings often appear to be inaccurate. Finally, there’s Ucloo, the Chinese people search, that last we heard was looking to raise a round of capital.

– Spock, the Silicon Valley start-up focused on people search, got off to a good start mid last month, when it hit the list of fastest growing sites, according to Alexa, even if it had some well-reported snafus (Spock lets users tag other people in profiles with words to describe them, and some people have complained about being tagged with insulting words). It joins Wink, another Silicon Valley company focused on people search.

–And this just in: There’s a new company called PeekYou. However, it looks considerably more lightweight, compared to Spock and others, perhaps because it has just launched, with less preparation than the others (Techcrunch has more).

Dailymotion, a Paris, France-based video-sharing site that’s a distant competitor to YouTube, has raised $34 million in funding, according to the Wall Street Journal.

The site, like many others, lets you share personal videos privately with friends or publicly with anyone. Like its competitors, people can also comment on each other’s videos, embed Dailymotion video clips in other sites, tag videos, view selected channels, etc.

However, Dailymotion has distinguished itself by tailoring its site to country locations. In France, it offers a French language site, and does community-building events there — for example, it months ago it started foster debate among French politicians, before YouTube started something similar here in the U.S. Dailymotion is neck and neck with YouTube for top ranked video site in that country. Dailymotion does something similar in Germany and other European countries. It lets people click on a flag icon at the top, for example the UK’s flag, if they want to view the site in English (see below)

Other distant competitors to YouTube have also raised large amounts of funding recently. Metacafe raised $30 million last week, Veoh raised $26 million in June.

One might call these sites also-rans compared to YouTube — YouTube has 61.77 percent of the US market, for example, while Daily Motion has 0.76 percent, according to Hitwise (table below). Internationally, the news is better for the company, as it was the ninth-fastest growing site on the web in May, with 28 million users, according to Comscore.

With these large cash infusions, these video sites may better described as also-runnings, not also rans. Video sites are expensive to run because they require the constant transfer of large amounts of video data between their own servers and end user’s computers — and need cash to pay for large amounts of traffic.

The hope of these investors, maybe, is that consumer web companies with solid traffic levels are still attractive purchases even if they aren’t market leaders. Many larger media companies are looking to establish their own online video brands, and have the money to buy their way into the market.

For example, Fotolog, a photo-sharing site not unlike Flickr (purchased last year by Yahoo) and Photobucket (purchased months ago by Fox/Myspace) was itself purchased last week by French media firm Hi-Media for $90 million.

New investors include Advent Venture Partners LLP and AGF Private Equity, which is a division of Allianz AG. Previous investors, Atlas Ventures and Partech International, participated in the round.

Curse, another online company that offers social networking around multi-player online games, has received a $5 million in a first round of venture capital funding.

Curse offers gamers the standard social networking features around their games, from image and video uploading, to blogging, social bookmarking, wikis, databases, forums and guild website hosting.

The funding, which comes from France’s AGF Private Equity and other individual investors, follows more than $800,000 in angel money, the company said in a statement. It also comes as venture capitalists are pumping money into a other companies doing similar things, from Multiverse, which provides a way for developers to produce their own games, to Napster co-founder Shawn Fanning’s Rupture, a more direct competitor that also builds social networking around existing games. On Tuesday, GuildCafe , a Cambridge, Mass. company that also lets gamers network, said it had raised an undisclosed amount of financing from IDG Ventures Boston.

Gaming remains hot. Silicon Valley angel investor Jeff Clavier recently told us he’d resumed investing in Internet companies again after a brief hiatus at the end of last year, in part because of the promise of online gaming.

Yoono is a tool that finds pages relevant to the one you are surfing on, and locates people who are also interested in that site.

This company is notable because similar players like StumbleUpon have become popular lately.

France-based Yoono relies on the goodwill of other users, however, requiring them 1) to download Yoono’s toolbar (and some users are now overwhelmed by toolbars) and then 2) give Yoono permission to search their bookmarks, which it then stores in its database. Yoono is a long-shot, we believe, because of these hurdles. However, after these two steps, there’s no more work required. In fact, your elderly aunt might figure this out — and she may not want to “tag,” which is the alternative used by other social search engines (StumbleUpon and Delicious).

Let’s take a straightforward example of how Yoono works. If you are surfing VentureBeat, you’ll see (partial screenshot below) that Yoono has searched its database for users who have bookmarked articles where VentureBeat is named. It then lists them in the sidebar at left, by relevance. VentureBeat broke the “Powerset” story, and so it is no surprise this story is high up in the article listings. At the far bottom of the sidebar, you’ll see links that Yoono has found in the bookmarks of people who have also saved VentureBeat as a bookmark (Gigaom and Techmeme are at the top; we’ve cut the screen, but dozens of other links follow).

Right now, there are no “Yoosers,” or people who have tastes that are similar to VentureBeat’s (likely because I haven’t opened up my bookmarks for Yoono to tap).

The company also has a “surprise” button, which is similar to StumbleUpon — it finds a site you might like based on the site you’re surfing.

Its business model is advertising. Ads will put in the sidebar. The company raised $2 million two months ago from AGF Private Equity. It has ten employees.

On Dec. 11, at the Paris Le Web 3 event, Yoono will add a blog search feature (which draws on the RSS feeds from sites contained in the 25 millions bookmarks in its database), and a new way to visualize the Yooser network (a control panel to search Yoosers by topic). The company says it has more than 200,000 users.