VentureBeat

TODAY’S HEADLINES:

• Arriva Pharma recaps with $6M for respiratory anti-inflammatory drugs (release)
• Genetic tester Sciona gets another $5.2M, distribution deal (VentureWire)
• Joint resurfacer Arthrosurface takes in $4M (release)
• Automated medication dispenser MDG Medical receives $14M in debt, equity (release)
• California Stem Cell raises funds for heart, neurodegenerative treatments (release)

Arriva Pharma recaps with $6M for respiratory anti-inflammatory drugs – Arriva Pharmaceuticals, an Alameda, Calif., drug developer focused on inflammatory respiratory disease, raised $6 million in a convertible-stock funding that recapitalized the company. Investors included Nordic Biotech and MPM BioVentures.

Arriva is working on a bioengineered form — that is, one that can be manufactured via biotech methods — of an enzyme called alpha-1 antitrypsin, which is currently derived from donated blood. Natural deficiencies of the enzyme are linked to lung disease, and Arriva hopes to use a manufactured version to treat hereditary emphysema.

The company has been locked in litigation over the rights to the enzyme with the Florida startup AlphaMed Pharmaceuticals (see our coverage here), and filed for bankruptcy protection last year, according to VentureWire. Now emerging from that process, Arriva is looking to start mid-stage, phase II trials of its recombinant enzyme. Arriva is a majority-owned unit of the Dutch firm Arriva Pharmaceuticals BV.

Genetic tester Sciona gets another $5.2M, distribution deal – Sciona, a Boulder, Colo., startup that offers genetic testing related to health and well-being, raised $5.2 million in a third funding round, VentureWire reports and the company confirms. Investors included Burrill & Co., BioVentures Investors, DSM Ventures, DFJ Esprit and BASF Venture Capital. The funding brings the company’s third round to a total of at least $15 million.

Sciona claims to combine nutrition and genetics in order to help individuals live healthier lifestyles. Its tests measure genetic predisposition to particular diseases and generates nutrition, exercise and lifestyle recommendations. You might think this sort of thing sounds like it runs way ahead of what science actually knows about genetic influence on our physical traits and disease susceptibility — and you’d almost certainly be right. The glitzy Web site for the company’s tests, which resembles a late-night TV infomercial, doesn’t exactly inspire confidence in the company’s scientific underpinnings, either.

On top of all that, Sciona just reached a distribution arrangement with Spa Team International that will provide the companies tests through a network of 1,000 spas nationwide.

TODAY’S HEADLINES:

• CyberHeart pumps in $9M for cardiac-arrhythmia treatment (release)
• Incubator ForSight launches third device company with $6M funding (release)
• Primera Biosystems raises $21M for molecular diagnostics (release)
• Biogen Idec, PDL BioPharma take stakes in Ophthotech (release)
• Technitrol acquires medical-device component maker Sonion for $385M (release)
• DLJ Merchant Banking takes control of dentristy-product maker Den-Mat (release)
• SV Life Sciences appoints Hamish Cameron as venture partner (release)

CyberHeart pumps in $9M for cardiac-arrhythmia treatment – CyberHeart, a Menlo Park, Calif., startup developing a non-invasive treatment for heart arrhythmias, raised $9 million in a first funding round. Investors included Emergent Medical Ventures, United Investments, Venture Select and Mitsubishi.

Arrythmias, which are irregular heartbeats often caused by a malfunction in the heart’s electrical-signaling system, are often treated via a catheter-based procedure that burns away tissue where the unusual rhythms originate. CyberHeart is working on hardware and software modifications for the CyberKnife system, a robotic radiosurgery device produced by Accuray, in order to extend its use in heart applications. In other words, CyberHeart’s adaptations will, if all goes well, allow doctors to perform the same sort of procedure non-invasively with the CyberKnife, an external radiation device that is supposed to deliver high-energy beams with submillimeter accuracy.

Incubator ForSight launches third device company with $6M funding – ForSight Labs, a medical-device incubator in Menlo Park, Calif., founded its third company, ForSight VISION3 and announced that it had raised $6 million in a first funding round. Investors included Morgenthaler Ventures, Split Rock Partners and Versant Ventures — all of whom, coincidentally, back ForSight as well.

ForSight hasn’t disclosed anything about the technology or approach that the new company will take, and in fact often remains secretive about its incubated companies for quite some time. In fact, the incubator sold its second company to QLT for $42 million plus milestone payments last October — a time the startup was known only as ForSight NewCo II.

Primera Biosystems raises $21M for molecular diagnostics – Mansfield, Mass.-based Primera Biosystems, a biotech developing molecular diagnostics, raised $21 million in a second funding round. Investors included Abingworth, Interwest Partners, Malaysian Technology Development Corporation, MPM Capital, Burrill & Co. and the Invus Group.

Primera’s gene-analysis system, which it calls STAR (short for “scalable transcription analysis routine”), is designed to read the activity of up to 100 genes at once with much greater sensitivity and precision than existing microarray technologies permit. The company plans to use the funding to complete development of its system, design future diagnostic tests in cancer and infectious disease, and produce test kits for clinical research.

Featured companies: American TeleCare, Gliknik, Juvaris BioTherapeutics, Medsphere Systems, Primera Biosystems

UPDATED: Expanded items on Juvaris, Medsphere, Primera, American TeleCare and Gliknik. Moved Broncus Tech and Aegerion Pharma items to an IPO roundup here.

Vaccine maker Juvaris Bio raises $12M, aims for $30M more — According to VentureWire (subscription required), this Pleasanton, Calif., vaccine maker raised $12 million in its first funding round. That appears to contradict an earlier item from PE Hub that said Juvaris BioTherapeutics had raised $16 million, according to a regulatory filing. The VentureWire story, however, is based on an interview with the Juvaris CEO, so we’ll run with that for now.

Kleiner Perkins Caufield & Byers provided the funding. Juvaris is developing vaccines against cancer and infectious disease using “adjuvants” — composed of DNA complexes and fatty molecules known as lipids — that stimulate immune responses. For additional coverage of the company, see here.

Juvaris also aims to raise another $30 million early next year to launch four clinical trials. Those trials will involve vaccines for influenza, hepatitis B, hepatitis C and acute myeloid leukemia.

Health-IT developer Medsphere raises $9M — Medsphere Systems, an Aliso Viejo, Calif., developer of open-source healthcare-IT systems, raised $9 million toward a third funding round, VentureWire reports. The company previously said it will target a $15 million round.

Existing investors Thomas Weisel Venture Partners, Azure Capital and Wasatch Venture Fund provided the funding, although Medsphere plans to bring new investors into the round as well. Medsphere has so far raised $16 million in equity and bridge loans, according to VentureWire.

The new fundraising is a sign that the once-troubled company may be turning itself around. Medsphere, which is developing a version of the VA’s electronic medical-record system VistA, recently settled a lawsuit the company had filed against its co-founding brothers that stemmed from a dispute over open-source software. Our previous coverage is here and here.

Gene analyzer Primera Biosystems pulls in $2.5M — Primera Biosystems, a Mansfield, Mass., developer of gene-activity analysis systems, raised $2.5 million in a second tranche of its first funding round, VentureWire reports, citing a regulatory filing. Investors included Malaysian Technology Development Corp., Burrill & Co. and MPM Capital.

Primera’s system combines two technologies — real-time PCR and microarray analysis — for use in basic research and clinical applications such as measuring viral load and drug resistance. The company last raised $11 million in 2005.

Remote healthcare-device maker American TeleCare raises $1.6M — American TeleCare, an Eden Prairie, Minn., maker of communication devices and technology for remote healthcare monitoring, raised $1.6 million from angel investors, VentureWire reports. The company has previously raised $16 million from angels.

From VentureWire: “American TeleCare provides technology and devices to help monitor patients with chronic conditions. The company’s products include audio, video and monitoring technology, including a telephonic stethoscope, with the aim of improving communication of patient information across the healthcare industry.”

Stealthy drug developer Gliknik raises $1.2M — Gliknik, a stealthy drug developer in Ruxton, Md., raised $1.2 million in seed funding, VentureWire reports. The company has drug candidates for cancer and autoimmune disease, although none are in human tests yet.

Although I try to stay on top of events in the life sciences, announcements do sometimes manage to slip through the cracks. Some days, in fact, I end up triaging. Because the roots of this site — not to mention many of its readers — are in Silicon Valley, Bay Area events are a priority. Then come announcements from the rest of the U.S., then Asia, then Europe. Also, smaller or partial fundings tend to take a backseat.

Looking back over my notes — it’s the only way I keep anything straight — I see quite a few of these orphans have piled up. So for the sake of completeness, I’m inaugurating this occasional feature to recap the fundings, mergers and IPOs that got away from me. I’ll put all the details below the fold, so only forge ahead if you’re really interested. RSS subscribers, unfortunately, are going to get the whole thing anyway.

Read the rest of this entry »

Snoqualmie, Wash.-based Light Sciences Oncology, a developer of light-activated cancer drugs, raised $30 million in a second funding round, even though it still has an IPO registration on file with the SEC. The latest funding closes out the company’s second round, which includes a $15 million investment by Fidelity Investments I wrote about here.

The company didn’t name its latest investors in its press release, but according to VentureWire they include Lehman Brothers, the hedge fund Deephaven Capital Management, the Malaysian Life Sciences Capital Fund, and Burrill & Co.

Test line: Technorati Profile

Pittsburgh-based Logical Therapeutics, a developer of drugs for inflammation and metabolic disease, raised $30 million in a second funding round and announced it is moving its headquarters to a location “near Boston.” (What are the odds that the new location might be Cambridge, the hub of biotech and pharma activity in the region?)

Logical has acquired all of its drug candidates from other companies or institutions, including the University of Pittsburgh, which isn’t particularly surprising given that it only has two employees. (It plans to expand to ten by early next year, according to VentureWire.) Its lead compound, LT-NS001, is a “prodrug” of the anti-inflammatory naproxen, better known as Aleve, meaning that the body’s enzymes will convert the drug into naproxen once ingested. Such prodrug forms are often designed to make drugs more effective by improving their ability to pass through the gastrointestinal tract. Other candidates include an oligopeptide for obesity and diabetes and another peptide that blocks tumor necrosis factor, or TNF, a protein that plays a key role in rheumatoid arthritis and other inflammatory conditions.

SV Life Sciences led the round, joined by Burrill & Co., Novo A/S, Sigvion Capital and Pennsylvania Early Stage Partners. Logical said the funding will allow the company to take LT-NS001 into mid-stage clinical trials.

Arete Therapeutics, a Hayward, Calif., developer of biotech cardiovascular treatments, raised a $35 million extension to its first round of funding. Founded in 2003, the company is working on “small molecule” drugs that target a metabolism-related chain of biochemical cellular signals that involves arachidonic acid. (If that isn’t enough to make your head hurt, the company has a detailed explanation here.) Drugs that interfere with that pathway could be useful in treating high blood pressure and inflammation; the company plans to move its first candidate into human testing later this year, according to VentureWire (subscription required).

Frazier Healthcare Investors and Alta Partners led the round, joined by Three Arch Partners, Burrill & Co. and Altitude Life Science Ventures. The company had previously raised $16 million in its first round in 2005, for a total so far of $51 million.

The company’s release is here (PDF).

Neosil, an Emeryville, Calif., company focused on dermatology products, raised a $10 million in venture debt from Hercules Technology Growth Capital. The debt funding follows the company’s $32 million first-round venture financing in 2004, which involved MPM Capital and Burrill & Co.

Neosil is developing a peptide-based hair-growth product for male pattern baldness and a topical antimicrobial treatment. It describes the debt financing here.