VentureBeat

TODAY’S HEADLINES:

• Acorn Cardio raises $22M for heart-failure device (bizjournals.com)
• Agile Therapeutics raises $5.6M for women’s health (release)
• Polyheal draws $1M for wound healing (Globes)
• MatrixBio receives seed funding for cancer diagnostics (release)
• Pacira Pharma names David Stack as CEO (release)
• VivoMetrics appoints Howard Baker as CEO (release)

Acorn Cardio raises $22M for heart-failure device – St. Paul, Minn.-based Acorn Cardiovascular, a device maker investigating a device that would restrain the expansion of failing hearts, raised $22 million in a new funding round. Investors included Cardinal Partners, Thoratec, SightLine Partners, Credit Suisse and New Enterprise Associates.

Acorn’s device, which it calls the CorCap, is a polyethylene mesh wrap that wraps around the heart, theoretically slowing or stopping the expansion that often occurs as hearts weaken and tire. The company sells the CorCap in Europe, but last year an FDA advisory panel recommended against approval of the device, throwing Acorn’s future into doubt until it reached an agreement with the FDA to conduct a new 50-patient trial. We previously covered Acorn’s travails and its primary venture competitor, the Sunnyvale, Calif., startup Paracor Medical, in this post.

Agile Therapeutics raises $5.6M for women’s health – Agile Therapeutics, a Princeton, N.J., specialty pharma focused on new contraceptives for women, raised $5.6 million in an extension of its fifth funding round, bringing the total for that round to $17.6 million. Investors in the round include the Hillman Company, ProQuest Investments, TL Ventures and Novitas Capital.

Agile’s lead product candidate is a low-dose estrogen patch for contraception, which is currently in mid-stage human trials. Agile suggests that the seven-day patch, which delivers steady doses of levonorgestrel and ethinyl estradiol, may help alleviate some side effects associated with high hormone exposure, such as breast tenderness, bloating or weight gain, and nausea.

Featured companies: AxoGen, Cognition Therapeutics, Ester Neurosciences, Gene Security Network, HealthTalk, MPM Capital, Revolution Health, SparkPeople

UPDATING: Expanded items on AxoGen, Ester and Cognition. Posted full items on MPM (link) and Gene Security Network (link).

AxoGen raises $12M for nerve regeneration — AxoGen, an Alachua, Fla., biotech focused on developing grafts for damaged “peripheral” nerves, raised $12.1 million in a third funding round. Investors included Accuitive Medical Ventures, Cardinal Partners, De Novo Ventures and Springboard Capital II.

AxoGen develops tissue grafts designed to preserve or restore the function of damaged nerves in the body’s periphery — areas such as the limbs, face or genitals. The company’s technology aims to “cleanse” nerve-graft tissue of substances that might inhibit nerve growth and regeneration — particularly one known as chondroitin sulfate proteoglycan — while preserving other factors that promote regrowth and integration of the grafted nerve.

The company launched its first peripheral-nerve graft product in July. AxoGen says the new funding will allow it to promote the product more vigorously.

Ester Neurosciences acquired by Amarin for $15M — Israel’s Ester Neurosciences, a biotech developing treatments for neurological conditions such as Alzheimer’s disease and multiple sclerosis, sold itself to Amarin of the U.K. for an upfront payment of $15 million plus up to $17 million in contingency payments. The release is here.

Ester’s lead program consists of a gene-silencing “antisense” drug for the neurodegenerative condition myasthenia gravis, which is now in a mid-stage test involving 18 patients. The company is also working with Pharmacopeia of the U.S. to develop small-molecule drugs that target variants of the AChE neurotransmitter that appear to be related to behavioral abnormalities or cognitive and motor degeneration.

HEADLINES OF NOTE:

• AxoGen raises $12M for nerve regeneration (release)
• Ester Neurosciences acquired by Amarin for $15M (release)
• Alzheimer’s drug developer Cognition Therapeutics raises $200K (release)
• RevolutionHealth acquires HealthTalk, invests in SparkPeople (release)
• MPM Capital looks for Indian life-science investments (VentureWire, sub req’d)
• Gene Security Network gets $4M for molecular diagnostics (release)

updated

AthenaHealth, a company that sells software to doctors to manage their billing and other office tasks, is just the latest company to appear cheated by the IPO process: It’s bankers helped it price the stock at $18, but by the end of the first day of trading, it was at $35.50.

That suggests the Watertown, Mass company could have sold its shares for much more, say $25 or $30, and still had decent demand from investors.

Here’s the quick math: It sold 6.19 million shares in the IPO, so had it judged the market more accurately, it could have brought in an extra $72 million had its banks helped it price a little higher. For a company losing $10 million a year, and with a feather-weight revenue of $80 million (see its prospectus for more), that’s a big deal.

Now, predicting a market price is difficult to do. And the responsibility for the pricing decision remains the company’s. But the banks, in this case Goldman Sachs and Merrill Lynch, have huge sway in the process, and have an interest in keeping a price artificially low. They get to turn around and sell the low stock to their favorite clients, giving them a huge pop for a profit — ensuring those clients will come back and do business with the banks.

This is just the latest sign that companies should look more closely at the OpenIPO auction process, pioneered by WR Hambrecht, which instead lets the market decide on the company’s price before the IPO. By opening the process to auction, it can factor in other demand trends (Dan Primack has more on what these may have been, in Athena’s case) that a closed-book ibank process can’t. The OpenIPO is what the stubbornly independently minded co-founders at Google did, after consulting with smart minds, but few others seem to have the guts.

AthenaHealth company had raised $50 million in funding from Oak Investment Partners, Draper Fisher Jurvetson, Venrock, and Cardinal Partners. The venture firms should be taking a closer look at the IPO process too.

Correction: An earlier version of this story incorrectly said the venture firms had sold part of their holdings in the IPO. They did not.

(UPDATED at 5:55pm PT: See below.)

Featured companies: Sierra Surgical Technologies, HerbalScience Nutraceuticals, Topigen Pharmaceuticals, EKR Therapeutics, Molecular Partners, Celsense, Glucose Sensing Technologies, Falcon Genomics, Waters, Calorimetry Sciences, Parion Sciences, Gilead Sciences, Isto Technologies, Fluidnet, NABsys

Sierra Surgical raises $7.1M — Palo Alto, Calif.-based Sierra Surgical Technologies, a developer of female sterilization technology, raised $7.1 million in a first funding round, PE Hub reports, citing a regulatory filing. Alta Partners and De Novo Ventures provided the funding.

Singapore’s HerbalScience raises $28M for natural extracts — HerbalScience Nutraceuticals, a Singapore-based natural-extracts company with offices in Naples, Fla., raised $28 million from the private-equity firms Aisling Capital and Weston Presidio, VentureWire reports (subscription required). The investment purchased a 25 percent stake in HerbalSciences, which makes purified extracts from various natural substances, valuing the company at $112 million.

Topigen Pharma pulls in $25M against lung disease — Montreal’s Topigen Pharmaceuticals, a biotech developing inhalable drugs to treat asthma and other lung diseases, raised $25 million (C$26 million) in a third funding round. Investors included NovaQuest, MMV Financial, BDC Venture Capital, Desjardins Venture Capital, Caisse de Dépot et Placement du Québec (Caisse), T2C2/BIO 2000 and Lothian Partners 27 (sarl) SICAR.

The funding will “accelerate” mid-stage human trials for Topigen’s leading drug candidates, a small-molecule treatment for chronic obstructive pulmonary disease and an RNA inhibitor for asthma.

EKR receives over $13M, licenses opiod drug — EKR Therapeutics, a Cedar Knolls, N.J., specialty pharmaceutical company, raised more than $13 million in a private placement. Investors included Quaker BioVentures, NewSpring Capital, and ESP Equity Partners. EKR also acquired rights to DepoDur, an extended-release opioid, from Pacira Pharmaceuticals.

Switzerland’s Molecular Partners gets $15.6M for novel binding proteins — Zurich-based Molecular Partners, a biotech developing drugs based on a new class of binding proteins, raised $15.6 million (CHF18.5 million) in a first funding round. Investors included Index Ventures, BB Biotech Ventures, Johnson & Johnson Development Corp. and Endeavour.

Molecular Partners is focused on developing therapeutics proteins it calls “DARPins,” which the company says offer the same ability to stick selectively to other molecules as monoclonal antibodies, but with greater stability and ease of manufacturing. DARPins are based on the notion of “repeat proteins,” which as the name suggests are modular proteins that contain repeated elements — something like posts spaced at regular intervals along a barbed-wire fence. (See the image at left.) The protein itself ends up looking something like a string that’s been knotted at regular intervals, only much more complicated.

Repeat proteins are found in almost all species, and in nature serve to bind other proteins in order to facilitate protein-protein reactions. By shuffling the modular elements in these proteins, they can be engineered to stick to specific molecules such as cell-surface proteins, potentially making them useful as drugs. The company has a more detailed description here.

Although Molecular Partners likes to play up the advantages of DARPins (the acronym stands for “designed ankyrin repeat proteins”) over antibodies — here, for instance — there are a few disadvantages the company doesn’t mention. As large molecules, DARPins most likely won’t get inside cells, limiting their potential as drugs to interactions with free-floating and cell-surface proteins. (Monoclonal antibodies have the same limitation.) Potentially more important, however, is the fact that the effectiveness of many antibody-based drugs results from their ability to stimulate a particular immune response, not just to stick to the appropriate target. DARPins, which aren’t immune-system molecules the way antibodies are, seem unlikely to do the same.

Pittsburgh-area biotechs, device makers get $350K — The Pittsburgh Life Sciences Greenhouse, a public-private life-sciences investment partnership, invested $350,000 in three Pittsburgh-area life-science startups. Falcon Genomics, a developer of chip-based cancer-detection diagnostics, received $150,000. Another $100,000 went to Celsense, which uses an MRI tracing agent to image transplanted cells. The final $100,000 was invested in Glucose Sensing Technologies, which is developing a catheter-based glucose sensor for continuous blood-sugar monitoring in intensive-care units.

Waters acquires Calorimetry Sciences — Milford, Mass.-based Waters, a laboratory-instrument maker, acquired Calorimetry Sciences of Linden, Utah. Terms of the deal weren’t announced. Calorimetry Sciences, which makes high-performance devices intended to measure the heat produced or absorbed by chemical reactions, will be merged into Waters’ TA Instruments division.

Fedora Commons wins $4.9M grant for open collaboration software — Fedora Commons, a non-profit organization devoted to open-source technologies for creating and sharing digital content, received a $4.9 million grant from the Gordon and Betty Moore Foundation. From the release:

With this funding, Fedora Commons will foster an open community to support the development and deployment of open source software, which facilitates open collaboration and open access to scholarly, scientific, cultural, and educational materials in digital form. The software platform developed by Fedora Commons with Gordon and Betty Moore Foundation funding will support a networked model of intellectual activity, whereby scientists, scholars, teachers, and students will use the Internet to collaboratively create new ideas, and build on, annotate, and refine the ideas of their colleagues worldwide. With its roots in the Fedora open-source repository system, developed since 2001 with support from the Andrew W. Mellon Foundation, the new software will continue to focus on the integrity and longevity of the intellectual products that underlie this new form of knowledge work. The result will be an open source software platform that both enables collaborative models of information creation and sharing, and provides sustainable repositories to secure the digital materials that constitute our intellectual, scientific, and cultural history.

Parion licenses lung-disease drug to Gilead for up to $146M — Parion Sciences, a Durham, N.C., biotech focused on diseases of the mucous membranes, struck a licensing and co-development deal with Gilead Sciences for its drug P-680 worth up to $146 million. The drug, an epithelial sodium-channel inhibitor, could potentially be useful in a variety of lung diseases, including cystic fibrosis. The companies will also work to identify other similar drug candidates.

Isto Tech raises $8.8M, prepares to launch synthetic bone grafts — St. Louis’ Isto Technologies, a developer of cell-based cartilage and bone regeneration technology, raised $8.8 million in a fifth funding round as it prepares for its first product launch, VentureWire reports. Investors included Ascension Health Ventures, Alafi Capital, Life Sciences Partners, Mid-America Transplant Services and private individuals. Isto’s leading product, InQu, is a synthetic biomaterial intended to help tissues heal and bones to regenerate; Isto expects FDA approval later this year.

Fluidnet rises from ashes, raises $6.4M for IV pumps — Portsmouth, N.H.-based Fluidnet, a “reincarnation” of its bankrupt predecessor FluidSense, raised $6.4 million in a first funding round to launch a new intravenous-infusion pump next year, VentureWire reports. Cardinal Partners and Rockport Venture Partners provided the funding.

NABsys raises $750K for high-speed genome sequencing — NABsys, a Providence, R.I., startup focused on high-speed gene-sequencing technologies, raised $750,000 in seed funding, VentureWire reports. Slater Technology Fund and individual investors provided the funding, which closely follows a $1.3 million grant from the National Institutes of Health.

UPDATE (10:55am PT): Added items on Molecular Partners and the Pittsburgh Life-Sciences Greenhouse investments.

UPDATE REDUX (5:55 pm PT): Added items on Waters/Calorimetry Sciences, Fedora Commons, Isto Technologies, Fluidnet, NABsys.