VentureBeat

Point Biomedical, a San Carlos, Calif., developer of new biomedical-imaging products, raised $25 million in a recapitalization, peHub reports. Such recapitalizations often amount to a kind of “reset button” for existing investors and lenders, and usually suggest that a startup has run into some kind of significant — but not insurmountable — obstacle.

Investors in the recap round include new investor Vedanta Opportunities Fund and existing investors William Blair Capital Partners, De Novo Ventures, Institutional Venture Partners, Saints Capital, Sprout Group and CHL Medical Partners. The recapitalization includes an additional $32.3 million that will become available to Point Bio once it attains an unspecified milestone, which it expects to occur in April.

There’s presumably a release about this, but Point Bio’s Web site has been down all morning, so for now I’m relying on peHub and VentureWire reports. I’ll update if the release turns up. According to VentureWire, Point Bio had previously raised over $110 million from a variety of venture-capital and private-equity firms.

Point Bio is developing a medical imaging and drug-delivery technology based on tiny, nested spheres it calls the BiSphere. This technology is currently in late-stage trials as an “imaging agent” that should make it possible to observe the flow of blood through the heart using ultrasound instead of more invasive methods. We previously covered the company when it raised money last July and described its technology in more detail there.

Featured companies: Mawell, OpGen, Vital Therapeutics

Optical genome-mapper OpGen raises $23.6M in a restart — OpGen, a Madison, Wisc., biotech developing a genomic test for identifying disease-causing microbes, raised $23.6 million in what the company is billing as a first funding round. In fact, however, the funding is more of a restart for the company, which was founded in 2001 and previously provided genomic services to researchers.

OpGen is now focused on developing speedy genome-based tests that can help identify and track infectious disease microbes. The company has set its sights on clinical microbiology laboratories as potential customers; such laboratories now try to identify the source of a patient’s infection by growing up the responsible bacterial in culture, a process that can take days. OpGen’s technology, which identifies patterns in single molecules of DNA to identify particular microbial strains, can deliver answers within two to three hours, the company says.

Investors included CHL Medical Partners, Highland Capital Partners, Versant Ventures and Mason Wells.

Vital Therapies gets $28.1M for artificial liver — San Diego’s Vital Therapies, a device maker developing an “artificial liver,” raised $28.1 million in a third funding round. Investors included Versant Ventures, Delphi Ventures, HBM BioMed China, DFJ DragonFund China, MedVenture Associates, Valley Ventures, Toucan Capital and Heights Capital.

Vital’s main focus is on a cartridge-style device that mimics the toxin-breakdown and waste-filtering function of the liver. The device, which contains artificially grown human liver cells, is intended for use while patients await a liver transplant. The device has completed four early-to-mid-stage trials, two of them in China, where prevalent hepatitis frequently contributed to liver failure.

Finland’s Mawell draws €8M for healthcare IT — Helsinki’s Mawell, a bioinformatics company providing software and services to drug companies and hospitals, raised €8 million ($11.1 million) from the private-equity firm CapMan, VentureWire reports (subscription required). CapMan will become Mawell’s largest owner.

BioRelix, a New Haven, Conn., developer of new antibiotics, raised $25.75 million in a first funding round, VentureWire reports (subscription required). The round included New Leaf Venture Partners, Aisling Capital, CHL Medical Partners, Novartis Venture Fund, Elm Street Ventures and Alexandria Real Estate Equities.

BioRelix is developing antibiotics that target what the company says are common stretches of bacterial RNA that control many functions essential for bacterial survival. The funding should allow the company to push a drug candidate into human tests by late 2009 or early 2010, its interim CEO told VentureWire.