VentureBeat

TODAY’S HEADLINES:

• Gene-silencing developer Santaris raises €20M (PDF release)
• Consumer-driven healthcare manager RedBrick Health prescribed $15M (release)
• Cardiac Dimensions takes in $36M for heart-valve device (release)
• TcLand Expressions gets €8.2M for biomarkers (PDF release)
• TheraQuest Bio gets $3M for pain drugs (release)
• Brain-software maker NeuroTrax visualizes $1.5M (VentureWire)
• ActivBiotics selling off assets after clot-busting drug failure (release)
• Nanostart buys stake in Singapore’s Curiox, a drug-discovery tech firm (release)
• Respiratory biotech Altair Thera gets additional funding (VentureWire)
• Specialty pharma Prometheus Labs files for $100M IPO (Edgar)
• Sirtris co-founder David Sinclair joins Lux Capital as venture partner (PDF release)

Gene-silencing developer Santaris raises €20M — Denmark’s Santaris Pharma, a developer of gene-silencing drugs, raised €20 million ($30 million) (PDF) in a third financing round. Investors included Gilde Healthcare Partners, BankInvest, Novo, LD, Forbion Capital Partners, Global Life Science Venture, Sunstone Capital, Seventure, Omega, Innovation Capital and members of the Company’s board and management. Gilde contributed €7.5 million to the round.

Santaris is pursuing an “antisense” strategy for turning off particular disease-related genes using synthetic strands of nucleic acid, which bind to and deactivate the messenger RNA molecules that are crucial to gene activity. (Technically, the mRNA plays a key role in the manufacture of a gene’s protein or proteins, which in disease states are often either malformed or overproduced. The drug molecule is a complement to the mRNA’s nucleic-acid sequence, which in DNA chemistry makes it an “antisense” molecule.)

Whereas biotechs working on antisense drugs have traditionally used strands of DNA — often chemically modified to improve their durability and cell-penetrating abilities — to block gene activity, Santaris has produced what it claims is a unique RNA analogue that it calls a “locked nucleic acid.” (The company goes into detail here.) The Santaris molecule, which combines LNA and DNA, is supposed to bind RNA in three dimensions, presumably boosting its binding ability and therefore potency.

Santaris is first targeting chronic lymphocytic leukemia, and says its drug candidate has already demonstrated initial safety and efficacy in an early-stage human test. The company has several other candidates in preclinical development, as well as two other molecules it licensed to Enzon Pharmaceuticals, one of which has also begun human testing against cancer.

For a more detailed look at antisense, see our coverage of Excaliard Pharmaceuticals, a biotech that licensed a slew of technology from antisense pioneer Isis Pharmaceuticals, here.

Consumer-driven healthcare manager RedBrick Health prescribed $15M — RedBrick Health, a Minneapolis healthcare company promoting “consumer-oriented” plans that shift much of the financial responsibility for medical care to individuals, raised $15 million in a second funding round. Investors included Fidelity Ventures, Highland Capital Partners and Versant Ventures.

RedBrick aims to help companies set up consumer-directed healthcare plans, which are also known as “defined contribution” schemes in that they limit the financial exposure of employers, who simply make regular contributions to employee “health savings accounts.” These plans, obviously, put the financial onus on individuals, who pay for their own medical care out of these accounts, in contrast to traditional “defined benefit” plans in which individuals pay premiums for comprehensive health coverage. In theory, these consumer-oriented plans should hold down healthcare costs by making individuals more “responsible” users of medical care; in practice, sick patients are often in a terrible position to be good medical “consumers,” and the plans have have proven generally unpopular to boot.

That hasn’t slowed RedBrick or its backers. The company will use the funding to continue expanding its efforts to sell and manage consumer-directed healthcare plans, which RedBrick somewhat misleadingly insists on calling “consumer-owned” healthcare. (Such plans usually couple health-savings accounts with a high-deductible insurance plan.) The company recently announced deals with several new client companies, although none are exactly what you’d call high profile firms — their ranks include the Ridgeview Medical Center in the Minneapolis-St. Paul area, which is switching its employees to a RedBrick-supported plan, and Welch Allyn, a medical-device manufacturer in Skaneateles Falls, N.Y., which is doing likewise.

Cardiac Dimensions takes in $36M for heart-valve device – Cardiac Dimensions, a Kirkland, Wash., developer of heart-valve devices, raised $35.5 million in a fourth financing round. Investors included Johnson & Johnson Development, Lumira Capital, Mitsubishi UFJ Capital, West River Capital, Montgomery & Co., Frazier Healthcare Ventures, Interwest Partners, MPM Capital, and Polaris Venture Partners.

Cardiac Dimensions is working on an implantable device designed to reshape the heart’s mitral valve, which in heart-failure patients sometimes weakens and allows blood to swish backward through the heart’s chambers. We’ve covered several other startups working on mitral-valve devices, including Evalve and Cardiosolutions.

Featured companies: AerovectRx, Dicerna Pharmaceuticals, Harmony Information Systems, Intelligent Hospital Systems, Merrion Pharmaceuticals, Syntaxin, SymBio Pharmaceuticals

UPDATED: Expanded items on Harmony Info, SymBio Pharma and Merrion Pharma, added Dicerna item.
UPDATE REDUX: Added Syntaxin item.

U.K. biotech Syntaxin raises £16M for pain and nervous-system drugs — Syntaxin, a U.K. biotech focused on drugs that affect cell secretion, raised £16 million ($33.2 million) in a second funding round. The company’s release is here.

Investors in the round included SR One, the venture capital arm of GlaxoSmithKline; Life Science Partners; Abingworth; Johnson & Johnson Development; and Quest for Growth. Syntaxin is developing drugs derived from bacterial toxins that block the release of chemicals known as neurotransmitters, which may be useful in treating pain, respiratory disease, neurological problems and obesity and related metabolic disorders.

Harmony Info, a healthcare IT provider, raises $28M to fund acquisition and expand sales — Reston, Va.-based Harmony Information Systems, a maker of healthcare software for government agencies and nonprofits, raised $28 million in a second funding round consisting of equity and debt. Investors included JMI Equity, Updata Partners, ORIX Venture Finance and Comerica Bank.

On Monday, Harmony announced the acquisition of rival Synergy Software Technologies for undisclosed terms. Harmony provides IT systems that handle electronic medical records, billing and insurance-claims management.

Japan’s SymBio Pharma closes in on ¥2B funding — Tokyo’s SymBio Pharmaceuticals, a specialty pharma founded in 2005, is near closing a ¥2 billion ($17.4 million) third round of funding, VentureWire reports (subscription required). The company is focused on acquiring and developing drugs for cancer, blood disease and autoimmune conditions.

Co-founder Lowell Sears, a former Amgen CFO and now CEO of Sears Capital Management, has long been active in the Asian pharmaceuticals market. From VentureWire:

He was a founding investor, for instance, in Peninsula Pharmaceuticals Inc., an Alameda, Calif.-based company that licensed late-stage antibiotics from Japanese companies. Johnson & Johnson acquired Peninsula in 2005, and Forest Laboratories Inc. bought Peninsula spinout Cerexa Inc. in January.

Sears and Fuminori Yoshida, whom Sears once hired to be president of Amgen’s Japanese unit, started SymBio to do the reverse of Peninsula by acquiring Asian product rights.

Like JapanBridge, an MPM Capital-founded company we wrote about here, SymBio essentially aims to acquire drugs or drug candidates from elsewhere in order to win regulatory approval and sell them in Japan.

Irish specialty pharma Merrion slashes IPO range — Dublin’s Merrion Pharmaceuticals, a specialty pharma we last checked in on over the weekend, sharply lowered its expected IPO range. The company, which had hoped to sell as many as 4.6 million shares (listed in the U.S. as American Depositary Shares) for $10 to $12, now expects only $6 to $7 per ADS.

That lowers Merrion’s maximum IPO take to $32.2 million, down from an earlier $55.2 million, and gives the company a post-offering market capitalization of up to $122.9 million. Merrion rejiggers existing drugs to make them easier to take by mouth.

New RNA-interference biotech Dicerna shoots for $13M, aims to work around RNAi patents — Dicerna Pharmaceuticals, a stealthy, Boston-based biotech in the field of RNA interference, aims to raise $13 million in a first funding round, the In Vivo blog reports. The company, co-founded by John Rossi of Duarte, Calif.’s City of Hope National Medical Center and Mark Behlke of Integrated DNA Technologies, is focused on making new drugs via the “gene-silencing” properties of RNAi while sidestepping a patent thicket that has grown up around the technology. The company expects to close its funding in November.

Unless you’re a nucleic-acid chemist (or a patent lawyer focused on same), the details of Dicerna’s strategy are most likely beside the point, although I’m sure the In Vivo folks would welcome your attention if you’re really interested. Suffice to say that the company’s founders believe they’re found a new way to build these gene-silencing molecules that isn’t covered by some of the fundamental patents in the field. If that’s true — and no one will really know for years, if ever — it could spark new attention from Big Pharma and other biotechs that have so far sat out the increasingly frantic, and expensive, race to make RNAi drugs.

As with any early-stage technology, it’s helpful to bear in mind that no one has yet demonstrated that RNAi molecules can even work as safe and effective drugs, much less that they’ll be the magic bullet that some have claimed. Still, a lot of money has been sloshing around the field recently (see our coverage in the third item here), and there’s little doubt that deep-pocketed folks still on the sidelines will want to at least check out Dicerna’s claims.

OTHER HEADLINES OF NOTE:

• IH Systems pulls in $7.6M for robot syringe-filler (release)
• AerovectRx names Ed Cannon as new CEO (release)

Featured companies: DirectFlow, Direvo, Indigo Biosystems, MacroGenics

Direct Flow raises $27M for heart-valve implants — Santa Rosa, Calif.-based Direct Flow Medical, a startup developing heart implants, raised $27 million in a second funding round. Investors included Johnson & Johnson Development, Foundation Medical Partners, VantagePoint Venture Partners, ePlanet, EDF Ventures, New Leaf Venture Partners and Spray Venture Partners.

Direct Flow makes minimally invasive aortic-valve replacements for the heart. This particular field happens to be booming — we’ve previously covered competitors JenaValve, AorTx and Sadra.

MacroGenics signs Eli Lilly pact worth initial $43M for autoimmune disease — MacroGenics, a Rockville, Md., biotech developing antibody-based therapies for autoimmune disease, signed a partnership with Eli Lilly that could be worth more than $600 million. MacroGenics is working on antibodies designed to tamp down autoimmune responses by inducing tolerance to antigens that might otherwise promote strong immune reactions to the body’s own cells. The company’s first drug candidate targets diabetes — specifically “type one” diabetes that results when the immune system targets insulin-producing cells in the pancreas.

OTHER HEADLINES OF NOTE:

• Indigo Biosystems gets funding for lab-data software (VentureWire, sub req’d)
• Germany’s Direvo pulls in €12M for biomanufacturing (release)

Featured companies: Biolipox, Cellpoint Diagnostics, Corum Medical, MediKeeper, Mendel Biotechnology, NanoMed, Orexo, Rules-Based Medicine, Tengion

UPDATED: Expanded the Tengion item, and that’s about it.

Tengion raises $33M for bladder regrowth — Tengion, a Norriton, Pa., biotech focused on regenerating diseased or damaged organs, raised $33 million in a third funding round. Investors included Deerfield Partners, Bain Capital, Johnson & Johnson Development, HealthCap, Quaker BioVentures, Oak Investment Partners, L Capital Partners, Horizon Technology Finance and Oxford Finance.

Tengion is working on growing new bladders for adults and children with spinal bifida or spinal-cord injuries based on cells biopsied from the patients’ own bladders. We mentioned the company briefly here.

OTHER HEADLINES OF NOTE:

• Biomarker lab Rules-Based Medicine gets $25M from private equity (release)
• Cancer-diagnostics firm CellPoint Diagnostics pulls in $11.2M (VentureWire, sub req’d)
• Swedish specialty pharma Orexo to acquire Biolipox for $133M (release)
• Cancer drug, diagnostic maker NanoMed gets $1.5M (VentureWire)
• Biocontrol raises £500 against antibiotic-resistant infections (release>
• Satoris reports potential blood test for Alzheimer’s disease (release)
• Corum Medical raises $225K, seeks $3.5M for anemia test (VentureWire)
• Mendel Biotech completes financing round (release)
• Health, wellness Web-tool developer MediKeeper raises funds (release)

Novocell, a San Diego embryonic stem-cell company, raised $25 million in a third round of funding. That’s presumably a bit of a letdown for the company, which had previously hoped to pull in as much as $35 million in the round. I wrote earlier about Novocell’s fundraising here.

The round was led by Johnson & Johnson Development, the venture arm of J&J itself, joined by Sanderling Ventures, Asset Management Company and Pacific Horizon Ventures.

In my earlier piece, I explored whether J&J’s involvement marked the first time that Big Pharma had directly funded an embryonic stem-cell company. It turns out that’s probably true, although J&J’s investment in Novocell dates back to at least 2005, a fact I didn’t learn until a few days after I wrote that post. (I had updated the previous item with that acknowledgement, but the update somehow got lost in WordPress, so I’ll just make the point again here.)

I’ve also heard from some sources that J&J’s interest isn’t so much in stem cells as in a separate Novocell technology for “encapsulating” cells to protect them from immune-system rejection after a transplant. Although that sort of technology might be useful for protecting stem-cell transplants, it’s also got potential utility outside the stem-cell field. For instance, if transplants of insulin-producing pancreatic islet cells ever became feasible as a diabetes treatment, encapsulation might be one way to ensure that the cell transplants “take” without forcing patients onto immunosuppressive drugs for the rest of their lives. (Exactly how to procure a reliable supply of islet cells is a separate problem, since donors and cadavers tend to be in short supply — and that’s where stem cells are likely to enter the picture.)

Novocell, in fact, is currently performing early-stage trials of exactly that sort of therapy, using islet cells procured from cadavers. The encapsulated cells are injected into “tissue pockets” just under the skin of the thighs or the lower abdomen. Last year, the company presented preliminary data from the study in which the cells transplanted into the first two treated diabetics appeared to show early signs of functioning without triggering an immune-rejection response.

Since the study was supposed to include 12 patients who would be monitored for 12 months, new data from that study might not be too far off, which probably helps explain J&J’s interest in leading this new round.

Biolex Therapeutics, a Pittsboro, N.C., developer of technology for improving the properties of monoclonal antibodies, raised $30 million in a third funding round.

Biolex specializes in producing proteins that are difficult to make with existing bioengineering processes and in optimizing the biological properties of monoclonal antibodies. It is also pursuing its own experimental drug candidates, and said the proceeds of this round will serve primarily to advance Locteron, an experimental time-release form of interferon alfa, into late-stage human tests against hepatitis C.

Investor Growth Capital led the round, joined by two other new investors, JP Morgan Securities and Easton Capital. Existing shareholders including Quaker BioVentures, Polaris Venture Partners, Intersouth Partners, Mitsui & Co. Venture Partners, Johnson & Johnson Development Corporation and Dow Venture Capital also participated. The company’s release is here (PDF).

CVRx, a Minneapolis-based developer of an implantable device for the control of high blood pressure, raised $65 million in a fourth round of funding that will support a “pivotal” clinical trial of the device. The round was led by Johnson & Johnson Development, and also included existing investors New Enterprise Associates, Thomas Weisel Healthcare Venture Partners, InterWest Partners, ABS Ventures, Frazier Healthcare Ventures and SightLine Partners. CVRx has so far raised a total of $125 million.

The company’s Rheos Baroreflex device is designed to stimulate the body’s own blood-pressure regulation system — known as the baroreflex — to control hypertension. It consists of an implantable pulse generator and two lead wires that are attached to the left and right carotid arteries. Using timed electrical stimulation, the device triggers the baroreflex, which in turn signals the brain to lower blood pressure throughout the body. This sort of “neuromodulation” approach is an increasingly hot area in medical-device development, although it remains largely unproven.