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	<title>VentureBeat &#187; islet cell transplants</title>
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		<title>VentureBeat &#187; islet cell transplants</title>
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		<title>Novocell: With diabetes study pending, investors pony up another $25M</title>
		<link>http://venturebeat.com/2007/07/20/novocell-with-diabetes-study-pending-investors-pony-up-another-25m/</link>
		<comments>http://venturebeat.com/2007/07/20/novocell-with-diabetes-study-pending-investors-pony-up-another-25m/#comments</comments>
		<pubDate>Fri, 20 Jul 2007 22:44:17 +0000</pubDate>
		<dc:creator>David P. Hamilton</dc:creator>
				<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[biotechnology]]></category>
		<category><![CDATA[deal]]></category>
		<category><![CDATA[diabetes]]></category>
		<category><![CDATA[islet cell transplants]]></category>
		<category><![CDATA[stem cells]]></category>

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		<description><![CDATA[<p>Novocell, a San Diego embryonic stem-cell company, raised $25 million in a third round of funding. That&#8217;s presumably a bit of a letdown for the company, which had  previously hoped to pull in as much as $35 million in the &#8230;</p><img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=venturebeat.com&amp;blog=342986&amp;post=21333&amp;subd=venturebeat&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p><a href="http://venturebeat.files.wordpress.com/2007/07/novocell_logo.gif" target="_blank"><img src='http://venturebeat.files.wordpress.com/2007/07/novocell_logo.thumbnail.gif' alt='novocell_logo.gif' /></a><a href="http://www.novocell.com/" target="_blank">Novocell</a>, a San Diego embryonic stem-cell company, <a href="http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&amp;STORY=/www/story/07-16-2007/0004626022&amp;EDATE=" target="_blank">raised $25 million in a third round of funding</a>. That&#8217;s presumably a bit of a letdown for the company, which had  previously hoped to pull in as much as $35 million in the round. I wrote earlier about Novocell&#8217;s fundraising <a href="http://venturebeat.com/2007/04/06/is-big-pharma-tiptoeing-into-embryonic-stem-cells-2/">here</a>.</p>
<p>The round was led by <a href="http://www.jjdevcorp.com/" target="_blank">Johnson &amp; Johnson Development</a>, the venture arm of <a href="http://www.jnj.com" target="_blank">J&amp;J</a> itself, joined by <a href="http://www.sanderling.com" target="_blank">Sanderling Ventures</a>, <a href="http://www.assetman.com" target="_blank">Asset Management Company</a> and <a href="http://www.pacifichorizon.com" target="_blank">Pacific Horizon Ventures</a>.</p>
<p>In my earlier piece, I explored whether J&amp;J&#8217;s involvement marked the first time that Big Pharma had directly funded an embryonic stem-cell company. It turns out that&#8217;s probably true, although J&amp;J&#8217;s investment in Novocell dates back to at least 2005, a fact I didn&#8217;t learn until a few days after I wrote that post. (I had updated the previous item with that acknowledgement, but the update somehow got lost in WordPress, so I&#8217;ll just make the point again here.)</p>
<p>I&#8217;ve also heard from some sources that J&amp;J&#8217;s interest isn&#8217;t so much in stem cells as in a separate Novocell technology for &#8220;encapsulating&#8221; cells to protect them from immune-system rejection after a transplant. Although that sort of technology might be useful for protecting stem-cell transplants, it&#8217;s also got potential utility outside the stem-cell field. For instance, if transplants of insulin-producing pancreatic islet cells ever became feasible as a diabetes treatment, encapsulation might be one way to ensure that the cell transplants &#8220;take&#8221; without forcing patients onto immunosuppressive drugs for the rest of their lives. (Exactly how to procure a reliable supply of islet cells is a separate problem, since donors and cadavers tend to be in short supply &#8212; and that&#8217;s where stem cells are likely to enter the picture.)</p>
<p>Novocell, in fact, is currently performing early-stage trials of <a href="http://www.novocell.com/clinical_trials.htm" target="_blank">exactly that sort of therapy</a>, using islet cells procured from cadavers. The encapsulated cells are injected into &#8220;tissue pockets&#8221; just under the skin of the thighs or the lower abdomen. Last year, the company presented <a href="http://www.novocell.com/press_release.php?title=PR_June_12_2006.htm" target="_blank">preliminary data from the study</a> in which the cells transplanted into the first two treated diabetics appeared to show early signs of functioning without triggering an immune-rejection response.</p>
<p>Since the study was <a href="http://www.clinicaltrials.gov/ct/show/NCT00260234?order=1" target="_blank">supposed to include 12 patients who would be monitored for 12 months</a>, new data from that study might not be too far off, which probably helps explain J&amp;J&#8217;s interest in leading this new round.</p>
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