Ultrasound clot-buster Ekos raises $10M in debt

Ekos, a Bothell, Wash., maker of ultrasound-enhanced drug-delivery systems, raised $10 million in debt capital from Hercules Technology Growth Capital. The financing will support the sales and marketing of drug-delivery catheters that feature an ultrasound system designed to help drugs break up blood clots more quickly. Ekos launched its catheters in early 2006.

Aperio, digital-pathology innovator, raises $11M

Aperio, a Vista, Calif., maker of systems that digitize medical images for use in the diagnosis of disease, raised $10.6 million from existing investors. It last raised $17 million in a second round of funding in Nov. 2005, and has now garnered a total of $33 million in equity capital. The company’s release is here.

Implant maker Interventional Spine draws in $24M

Irvine, Calif.-based Interventional Spine raised $24 million in a third round of funding that the company says will support the launch of several new products. The company makes implants and surgical instruments for “percutaneous” spinal operations that feature narrow incisions and, theoretically, less trauma for patients. Here is the company’s release.

SpectraGenics draws at least $20M for laser hair removal

SpectraGenics, a Pleasanton, Calif., developer of laser hair-removal devices for home use, raised at least $20 million in a fourth round of funding, VentureWire reports (subscription required). The round was led by De Novo Ventures and Technology Partners; other investors included Aphelion Capital, Incubic Venture Capital and SDL Ventures.

Implant maker Amedica files for $75M IPO

Salt Lake City-based Amedica filed to raise up to $74.8 million in an IPO, just a week after it raised $13.2 million in a fourth funding round. The maker of ceramic implants for spinal and joint repair said it doesn’t expect its first products to reach the market until next year.

Interlace Medical, women's health company, picks up $5M

Interlace Medical, a stealthy Newton, Mass., developer of gynecological devices, raised $5 million in a first round of funding, VentureWire reports. Spray Ventures and New Leaf Venture Partners led the round. PE Wire reports that the startup is focused on the market for polypectomies and myomectomies, which are surgeries for the removal of polyps and fibroids.

StrataGent closes $16M round for needle-free injections

StrataGent Life Sciences, a San Jose developer of needle-free “microjet” injection systems, said it closed a $16 million second round of financing. The company has so far received $6.65 million of that round; the remainder should become available next year if and when StrataGent meets certain milestones.

CVRx, developer of hypertension-treatment devices, draws in $65M

CVRx, a Minneapolis-based developer of an implantable device for the control of high blood pressure, raised $65 million in a fourth round of funding that will support a “pivotal” clinical trial of the device. The round was led by Johnson & Johnson Development, and also included existing investors New Enterprise Associates, Thomas Weisel Healthcare Venture Partners, InterWest Partners, ABS Ventures, Frazier Healthcare Ventures and SightLine Partners. CVRx has so far raised a total of $125 million.